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dc.contributor.authorVõsa, Urmoen_US
dc.contributor.authorEsko, Tõnuen_US
dc.contributor.authorKasela, Silvaen_US
dc.contributor.authorAnnilo, Tarmoen_US
dc.date.accessioned2015-11-03T15:58:04Z
dc.date.issued2015en_US
dc.identifier.citationVõsa, Urmo, Tõnu Esko, Silva Kasela, and Tarmo Annilo. 2015. “Altered Gene Expression Associated with microRNA Binding Site Polymorphisms.” PLoS ONE 10 (10): e0141351. doi:10.1371/journal.pone.0141351. http://dx.doi.org/10.1371/journal.pone.0141351.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:23473973
dc.description.abstractAllele-specific gene expression associated with genetic variation in regulatory regions can play an important role in the development of complex traits. We hypothesized that polymorphisms in microRNA (miRNA) response elements (MRE-SNPs) that either disrupt a miRNA binding site or create a new miRNA binding site can affect the allele-specific expression of target genes. By integrating public expression quantitative trait locus (eQTL) data, miRNA binding site predictions, small RNA sequencing, and Argonaute crosslinking immunoprecipitation (AGO-CLIP) datasets, we identified genetic variants that can affect gene expression by modulating miRNA binding efficiency. We also identified MRE-SNPs located in regions associated with complex traits, indicating possible causative mechanisms associated with these loci. The results of this study expand the current understanding of gene expression regulation and help to interpret the mechanisms underlying eQTL effects.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0141351en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619707/pdf/en
dash.licenseLAAen_US
dc.titleAltered Gene Expression Associated with microRNA Binding Site Polymorphismsen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorEsko, Tõnuen_US
dc.date.available2015-11-03T15:58:04Z
dc.identifier.doi10.1371/journal.pone.0141351*
dash.contributor.affiliatedEsko, Tõnu


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