A Solvent-Free Thermosponge Nanoparticle Platform for Efficient Delivery of Labile Proteins
Choi, Won Il
MetadataShow full item record
CitationChoi, W. I., N. Kamaly, L. Riol-Blanco, I. Lee, J. Wu, A. Swami, C. Vilos, et al. 2014. “A Solvent-Free Thermosponge Nanoparticle Platform for Efficient Delivery of Labile Proteins.” Nano Letters 14 (11): 6449-6455. doi:10.1021/nl502994y. http://dx.doi.org/10.1021/nl502994y.
AbstractProtein therapeutics have gained attention recently for treatment of a myriad of human diseases due to their high potency and unique mechanisms of action. We present the development of a novel polymeric thermosponge nanoparticle for efficient delivery of labile proteins using a solvent-free polymer thermo-expansion mechanism with clinical potential, capable of effectively delivering a range of therapeutic proteins in a sustained manner with no loss of bioactivity, with improved biological half-lives and efficacy in vivo.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:23474013
- HMS Scholarly Articles