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dc.contributor.authorGiedt, Randy J.en_US
dc.contributor.authorSprachman, Melissa M.en_US
dc.contributor.authorYang, Katherine S.en_US
dc.contributor.authorWeissleder, Ralphen_US
dc.date.accessioned2015-11-03T15:58:30Z
dc.date.issued2014en_US
dc.identifier.citationGiedt, Randy J., Melissa M. Sprachman, Katherine S. Yang, and Ralph Weissleder. 2014. “Imaging Cellular Distribution of Bcl Inhibitors Using Small Molecule Drug Conjugates.” Bioconjugate Chemistry 25 (11): 2081-2085. doi:10.1021/bc500433k. http://dx.doi.org/10.1021/bc500433k.en
dc.identifier.issn1043-1802en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:23474046
dc.description.abstractOverexpression of anti-apoptotic proteins such as Bcl-2 is a cellular mechanism to evade apoptosis; consequently, Bcl-2 inhibitors are being developed as anticancer agents. In this work, we have synthesized a fluorescent version of ABT-199 in an effort to visualize a drug surrogate by high resolution imaging. We show that this fluorescent conjugate has comparable Bcl-2 binding efficacy and cell line potency to the parent compound and can be used as an imaging agent in several cancer cell types. We anticipate that this agent will be a valuable tool for studying the single-cell distribution and pharmacokinetics of ABT-199 as well the broader group of BH3-mimetics.en
dc.language.isoen_USen
dc.publisherAmerican Chemical Societyen
dc.relation.isversionofdoi:10.1021/bc500433ken
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240345/pdf/en
dash.licenseLAAen_US
dc.subjectArticleen
dc.titleImaging Cellular Distribution of Bcl Inhibitors Using Small Molecule Drug Conjugatesen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalBioconjugate Chemistryen
dash.depositing.authorSprachman, Melissa M.en_US
dc.date.available2015-11-03T15:58:30Z
dc.identifier.doi10.1021/bc500433k*
dash.contributor.affiliatedSprachman, Melissa M.
dash.contributor.affiliatedYang, Katherine
dash.contributor.affiliatedWeissleder, Ralph


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