Nuclear respiratory factor 2 induces SIRT3 expression

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Nuclear respiratory factor 2 induces SIRT3 expression

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Title: Nuclear respiratory factor 2 induces SIRT3 expression
Author: Satterstrom, F Kyle; Swindell, William R; Laurent, Gaëlle; Vyas, Sejal; Bulyk, Martha L; Haigis, Marcia C

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Citation: Satterstrom, F Kyle, William R Swindell, Gaëlle Laurent, Sejal Vyas, Martha L Bulyk, and Marcia C Haigis. 2015. “Nuclear respiratory factor 2 induces SIRT3 expression.” Aging Cell 14 (5): 818-825. doi:10.1111/acel.12360. http://dx.doi.org/10.1111/acel.12360.
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Abstract: The mitochondrial deacetylase SIRT3 regulates several important metabolic processes. SIRT3 is transcriptionally upregulated in multiple tissues during nutrient stresses such as dietary restriction and fasting, but the molecular mechanism of this induction is unclear. We conducted a bioinformatic study to identify transcription factor(s) involved in SIRT3 induction. Our analysis identified an enrichment of binding sites for nuclear respiratory factor 2 (NRF-2), a transcription factor known to play a role in the expression of mitochondrial genes, in the DNA sequences of SIRT3 and genes with closely correlated expression patterns. In vitro, knockdown or overexpression of NRF-2 modulated SIRT3 levels, and the NRF-2α subunit directly bound to the SIRT3 promoter. Our results suggest that NRF-2 is a regulator of SIRT3 expression and may shed light on how SIRT3 is upregulated during nutrient stress.
Published Version: doi:10.1111/acel.12360
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568969/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:23474062
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