Hybrid Biosynthesis of Roseobacticides from Algal and Bacterial Precursor Molecules

DSpace/Manakin Repository

Hybrid Biosynthesis of Roseobacticides from Algal and Bacterial Precursor Molecules

Citable link to this page

 

 
Title: Hybrid Biosynthesis of Roseobacticides from Algal and Bacterial Precursor Molecules
Author: Seyedsayamdost, Mohammad R.; Wang, Rurun; Kolter, Roberto; Clardy, Jon

Note: Order does not necessarily reflect citation order of authors.

Citation: Seyedsayamdost, Mohammad R., Rurun Wang, Roberto Kolter, and Jon Clardy. 2014. “Hybrid Biosynthesis of Roseobacticides from Algal and Bacterial Precursor Molecules.” Journal of the American Chemical Society 136 (43): 15150-15153. doi:10.1021/ja508782y. http://dx.doi.org/10.1021/ja508782y.
Full Text & Related Files:
Abstract: Roseobacticides regulate the symbiotic relationship between a marine bacterium (Phaeobacter inhibens) and a marine microalga (Emiliania huxleyi). This relationship can be mutualistic, when the algal host provides food for the bacteria and the bacteria produce growth hormones and antibiotics for the algae, or parasitic, when the algae senesce and release p-coumaric acid. The released p-coumaric acid causes the bacteria to synthesize roseobacticides, which are nM−μM toxins for the algae. We examined the biosynthesis of roseobacticides and report that all roseobacticide precursors play critical roles during the mutualist phase of the symbiosis. Roseobacticides are biosynthesized from the algal growth promoter, the major food molecule provided by the algal cells, and the algal senescence signal that initiates the mutualist-to-parasite switch. Thus, molecules that are beneficial during mutualism are diverted to the synthesis of toxins during parasitism. A plausible mechanism for assembling roseobacticides from these molecules is proposed.
Published Version: doi:10.1021/ja508782y
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227733/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:23474077
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters