An Epigenome-Wide Association Study of Total Serum Immunoglobulin E Concentration

DSpace/Manakin Repository

An Epigenome-Wide Association Study of Total Serum Immunoglobulin E Concentration

Citable link to this page

 

 
Title: An Epigenome-Wide Association Study of Total Serum Immunoglobulin E Concentration
Author: Liang, Liming; Willis-Owen, Saffron A.G.; Laprise, Catherine; Wong, Kenny C.C.; Davies, Gwyneth A.; Hudson, Thomas J.; Binia, Aristea; Hopkin, Julian M.; Yang, Ivana V.; Grundberg, Elin; Busche, Stephan; Hudson, Marie; Rönnblom, Lars; Pastinen, Tomi M.; Schwartz, David A.; Lathrop, G. Mark; Moffatt, Miriam F.; Cookson, William O.C.M.

Note: Order does not necessarily reflect citation order of authors.

Citation: Liang, L., S. A. Willis-Owen, C. Laprise, K. C. Wong, G. A. Davies, T. J. Hudson, A. Binia, et al. 2014. “An Epigenome-Wide Association Study of Total Serum Immunoglobulin E Concentration.” Nature 520 (7549): 670-674. doi:10.1038/nature14125. http://dx.doi.org/10.1038/nature14125.
Full Text & Related Files:
Abstract: Immunoglobulin E (IgE) is a central mediator of allergic (atopic) inflammation. Therapies directed against IgE benefit hay fever1 and allergic asthma1,2. Genetic association studies have not yet identified novel therapeutic targets or pathways underlying IgE regulation3-6. We therefore surveyed epigenetic association between serum IgE concentrations and methylation at loci concentrated in CpG islands (CGI) genome-wide in 95 nuclear pedigrees, using DNA from peripheral blood leukocytes (PBL). We validated positive results in additional families and in subjects from the general population. We show here replicated associations with a meta-analysis false discovery rate <10−4 between IgE and low methylation at 36 loci. Genes annotated to these loci encode known eosinophil products, and also implicate phospholipid inflammatory mediators, specific transcription factors, and mitochondrial proteins. We confirmed that methylation at these loci differed significantly in isolated eosinophils from subjects with and without high IgE levels. The top three loci accounted for 13% of IgE variation in the primary subject panel, explaining 10 fold higher variance than that derived from large SNP GWAS3,4. The study identifies novel therapeutic targets and biomarkers for patient stratification for allergic diseases.
Published Version: doi:10.1038/nature14125
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416961/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:23474084
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters