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dc.contributor.authorRomano, Megan E.en_US
dc.contributor.authorEnquobahrie, Daniel A.en_US
dc.contributor.authorSimpson, Christopher D.en_US
dc.contributor.authorCheckoway, Harveyen_US
dc.contributor.authorWilliams, Michelle A.en_US
dc.date.accessioned2015-11-03T15:59:01Z
dc.date.issued2015en_US
dc.identifier.citationRomano, Megan E., Daniel A. Enquobahrie, Christopher D. Simpson, Harvey Checkoway, and Michelle A. Williams. 2015. “A Case-Cohort Study of Cadmium Body Burden and Gestational Diabetes Mellitus in American Women.” Environmental Health Perspectives 123 (10): 993-998. doi:10.1289/ehp.1408282. http://dx.doi.org/10.1289/ehp.1408282.en
dc.identifier.issn0091-6765en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:23474087
dc.description.abstractBackground: Environmental cadmium (Cd) exposure is associated with type 2 diabetes. However, the association of Cd and gestational diabetes mellitus (GDM) is unknown. Objectives: We examined the association between body burden of Cd and GDM risk. Methods: We used 140 GDM cases and 481 randomly selected noncase subcohort members from the Omega Study to conduct a case-cohort study. Creatinine (Cr)–corrected Cd in early pregnancy urine (U-Cd) was measured by inductively coupled plasma mass spectrometry. Tertiles (< 0.29; 0.29–0.42; ≥ 0.43 μg/g Cr) were defined using the subcohort’s U-Cd distribution. GDM was diagnosed using the 2004 American Diabetes Association guidelines. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression. Results: GDM cases had higher geometric mean U-Cd (0.39 μg/g Cr; 95% CI: 0.37, 0.41) than noncases (0.31 μg/g Cr; 95% CI: 0.29, 0.33). Odds ratios for GDM increased with increasing U-Cd tertile (OR = 1.64; 95% CI: 0.88, 3.05 for middle vs. low tertile; OR = 2.07; 95% CI: 1.15, 3.73 for high vs. low tertile; p-trend = 0.015). Overweight/obesity (body mass index ≥ 25 kg/m2) did not modify the association between U-Cd and GDM (p = 0.26). Conclusions: Our findings suggest that body burden of Cd increases risk of GDM in a dose-dependent manner. Improved understanding of environmental factors influencing GDM may facilitate early identification of women at high risk of GDM. Citation Romano ME, Enquobahrie DA, Simpson CD, Checkoway H, Williams MA. 2015. A case-cohort study of cadmium body burden and gestational diabetes mellitus in American women. Environ Health Perspect 123:993–998; http://dx.doi.org/10.1289/ehp.1408282en
dc.language.isoen_USen
dc.publisherNLM-Exporten
dc.relation.isversionofdoi:10.1289/ehp.1408282en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590743/pdf/en
dash.licenseLAAen_US
dc.titleA Case-Cohort Study of Cadmium Body Burden and Gestational Diabetes Mellitus in American Womenen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalEnvironmental Health Perspectivesen
dash.depositing.authorWilliams, Michelle A.en_US
dc.date.available2015-11-03T15:59:01Z
dc.identifier.doi10.1289/ehp.1408282*
dash.contributor.affiliatedWilliams, Michelle


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