The associations between Parkinson’s disease and cancer: the plot thickens

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The associations between Parkinson’s disease and cancer: the plot thickens

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Title: The associations between Parkinson’s disease and cancer: the plot thickens
Author: Feng, Danielle D.; Cai, Waijiao; Chen, Xiqun

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Citation: Feng, Danielle D., Waijiao Cai, and Xiqun Chen. 2015. “The associations between Parkinson’s disease and cancer: the plot thickens.” Translational Neurodegeneration 4 (1): 20. doi:10.1186/s40035-015-0043-z. http://dx.doi.org/10.1186/s40035-015-0043-z.
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Abstract: Epidemiological studies support a general inverse association between the risk of cancer development and Parkinson’s disease (PD). In recent years however, increasing amount of eclectic evidence points to a positive association between PD and cancers through different temporal analyses and ethnic groups. This positive association has been supported by several common genetic mutations in SNCA, PARK2, PARK8, ATM, p53, PTEN, and MC1R resulting in cellular changes such as mitochondrial dysfunction, aberrant protein aggregation, and cell cycle dysregulation. Here, we review the epidemiological and biological advances of the past decade in the association between PD and cancers to offer insight on the recent and sometimes contradictory findings.
Published Version: doi:10.1186/s40035-015-0043-z
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620601/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:23474139
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