Racial Differences in Circulating Natriuretic Peptide Levels: The Atherosclerosis Risk in Communities Study
View/ Open
Author
Gupta, Deepak K
Wells, Quinn
Li, Man
Maruthur, Nisa
Selvin, Elizabeth
Coresh, Josef
Konety, Suma
Butler, Kenneth R
Mosley, Thomas
Boerwinkle, Eric
Hoogeveen, Ron
Ballantyne, Christie M
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.1161/JAHA.115.001831Metadata
Show full item recordCitation
Gupta, D. K., B. Claggett, Q. Wells, S. Cheng, M. Li, N. Maruthur, E. Selvin, et al. 2015. “Racial Differences in Circulating Natriuretic Peptide Levels: The Atherosclerosis Risk in Communities Study.” Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease 4 (5): e001831. doi:10.1161/JAHA.115.001831. http://dx.doi.org/10.1161/JAHA.115.001831.Abstract
Background: Natriuretic peptides promote natriuresis, diuresis, and vasodilation. Experimental deficiency of natriuretic peptides leads to hypertension (HTN) and cardiac hypertrophy, conditions more common among African Americans. Hospital-based studies suggest that African Americans may have reduced circulating natriuretic peptides, as compared to Caucasians, but definitive data from community-based cohorts are lacking. Methods and Results: We examined plasma N-terminal pro B-type natriuretic peptide (NTproBNP) levels according to race in 9137 Atherosclerosis Risk in Communities (ARIC) Study participants (22% African American) without prevalent cardiovascular disease at visit 4 (1996–1998). Multivariable linear and logistic regression analyses were performed adjusting for clinical covariates. Among African Americans, percent European ancestry was determined from genetic ancestry informative markers and then examined in relation to NTproBNP levels in multivariable linear regression analysis. NTproBNP levels were significantly lower in African Americans (median, 43 pg/mL; interquartile range [IQR], 18, 88) than Caucasians (median, 68 pg/mL; IQR, 36, 124; P<0.0001). In multivariable models, adjusted log NTproBNP levels were 40% lower (95% confidence interval [CI], −43, −36) in African Americans, compared to Caucasians, which was consistent across subgroups of age, gender, HTN, diabetes, insulin resistance, and obesity. African-American race was also significantly associated with having nondetectable NTproBNP (adjusted OR, 5.74; 95% CI, 4.22, 7.80). In multivariable analyses in African Americans, a 10% increase in genetic European ancestry was associated with a 7% (95% CI, 1, 13) increase in adjusted log NTproBNP. Conclusions: African Americans have lower levels of plasma NTproBNP than Caucasians, which may be partially owing to genetic variation. Low natriuretic peptide levels in African Americans may contribute to the greater risk for HTN and its sequalae in this population.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599412/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:23474159
Collections
- HMS Scholarly Articles [17922]
- SPH Scholarly Articles [6362]
Contact administrator regarding this item (to report mistakes or request changes)