Protein mediated membrane adhesion

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Protein mediated membrane adhesion

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Title: Protein mediated membrane adhesion
Author: Carlson, Andreas; Mahadevan, Lakshminarayanan

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Citation: Carlson, Andreas, and L. Mahadevan. 2015. “Protein Mediated Membrane Adhesion.” Phys. Fluids 27 (5) (May): 051901. Portico. doi:10.1063/1.4919777.
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Abstract: Adhesion in the context of mechanical attachment, signaling, and movement in cellular dynamics is mediated by the kinetic interactions between membrane embedded proteins in an aqueous environment. Here, we present a minimal theoretical framework for the dynamics of membrane adhesion that accounts for the kinetics of protein binding, the elastic deformation of the membrane, and the hydrodynamics of squeeze flow in the membrane gap. We analyze the resulting equations using scaling estimates to characterize the spatiotemporal features of the adhesive patterning and corroborate them using numerical simulations. In addition to characterizing aspects of cellular dynamics, our results might also be applicable to a range of phenomena in physical chemistry and materials science where flow, deformation, and kinetics are coupled to each other in slender geometries.
Published Version: doi:10.1063/1.4919777
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