Terminal Schwann Cells Participate in Neuromuscular Synapse Remodeling during Reinnervation following Nerve Injury

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Terminal Schwann Cells Participate in Neuromuscular Synapse Remodeling during Reinnervation following Nerve Injury

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Title: Terminal Schwann Cells Participate in Neuromuscular Synapse Remodeling during Reinnervation following Nerve Injury
Author: Kang, Hyuno; Tian, Le; Mikesh, Michelle; Lichtman, Jeff; Thompson, Wesley J.

Note: Order does not necessarily reflect citation order of authors.

Citation: Kang, H., L. Tian, M. Mikesh, J. W. Lichtman, and W. J. Thompson. 2014. “Terminal Schwann Cells Participate in Neuromuscular Synapse Remodeling During Reinnervation Following Nerve Injury.” Journal of Neuroscience 34 (18) (April 30): 6323–6333. doi:10.1523/jneurosci.4673-13.2014.
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Abstract: Schwann cells (SCs) at neuromuscular junctions (NMJs) play active roles in synaptic homeostasis and repair. We have studied how SCs contribute to reinnervation of NMJs using vital imaging of mice whose motor axons and SCs are transgenically labeled with different colors of fluorescent proteins. Motor axons most commonly regenerate to the original synaptic site by following SC-filled endoneurial tubes. During the period of denervation, SCs at the NMJ extend elaborate processes from the junction, as shown previously, but they also retract some processes from territory they previously occupied within the endplate. The degree of this retraction depends on the length of the period of denervation. We show that the topology of the remaining SC processes influences the branching pattern of regenerating axon terminals and the redistribution of acetylcholine receptors (AChRs). Upon arriving at the junction, regenerating axons follow existing SC processes within the old synaptic site. Some of the AChR loss that follows denervation is correlated with failure of portions of the old synaptic site that lack SC coverage to be reinnervated. New AChR clustering is also induced by axon terminals that follow SC processes extended during denervation. These observations show that SCs participate actively in the remodeling of neuromuscular synapses following nerve injury by their guidance of axonal reinnervation.
Published Version: 10.1523/JNEUROSCI.4673-13.2014
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004816/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:23675517
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