Rat Olfactory Bulb Mitral Cells Receive Sparse Glomerular Inputs
Fantana, Antoniu L.
Soucy, Edward R.
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CitationFantana, Antoniu L., Edward R. Soucy, and Markus Meister. 2008. Rat olfactory bulb mitral cells receive sparse glomerular inputs. Neuron 59(5): 802–814. Homepage for Neuron: http://www.cell.com/neuron/home
AbstractCenter-surround receptive fields are a fundamental unit of brain organization. It has been proposed that olfactory bulb mitral cells exhibit this functional circuitry, with excitation from one glomerulus and inhibition from a broad field of glomeruli within reach of the lateral dendrites. We investigated this hypothesis using a combination of in vivo intrinsic imaging, single-unit recording, and a large panel of odors. Assuming a broad inhibitory field, a mitral cell would be influenced by >100 contiguous glomeruli and should respond to many odors. Instead, the observed response rate was an order of magnitude lower. A quantitative model indicates that mitral cell responses can be explained by just a handful of glomeruli. These glomeruli are spatially dispersed on the bulb and represent a broad range of odor sensitivities. We conclude that mitral cells do not have center-surround receptive fields. Instead, each mitral cell performs a specific computation combining a small and diverse set of glomerular inputs.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:2379543
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