Show simple item record

dc.contributor.authorPark, Seung-Yeolen_US
dc.contributor.authorYang, Jia-Shuen_US
dc.contributor.authorSchmider, Angela B.en_US
dc.contributor.authorSoberman, Roy J.en_US
dc.contributor.authorHsu, Victor W.en_US
dc.date.accessioned2015-12-04T18:13:23Z
dc.date.issued2015en_US
dc.identifier.citationPark, Seung-Yeol, Jia-Shu Yang, Angela B. Schmider, Roy J. Soberman, and Victor W. Hsu. 2015. “Coordinated regulation of bidirectional COPI transport at the Golgi by cdc42.” Nature 521 (7553): 529-532. doi:10.1038/nature14457. http://dx.doi.org/10.1038/nature14457.en
dc.identifier.issn0028-0836en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:23845175
dc.description.abstractThe Golgi complex plays a central role in the intracellular sorting of secretory proteins 1,2. Anterograde transport through the Golgi has been explained by the movement of Golgi cisternae, known as cisternal maturation 3–5. Because this explanation is now appreciated to be incomplete 6, interest has developed in understanding tubules that connect the Golgi cisternae 7–9. Here, we find that the Coat Protein I (COPI) complex sorts anterograde cargoes into these tubules. Moreover, the small GTPase cdc42 regulates bidirectional Golgi transport by targeting the dual functions of COPI in cargo sorting and carrier formation. Cdc42 also directly imparts membrane curvature in promoting COPI tubule formation. Our findings further reveal that COPI tubular transport complements cisternal maturation in explaining how anterograde Golgi transport is achieved, and that bidirectional COPI transport is modulated by environmental cues through cdc42.en
dc.language.isoen_USen
dc.relation.isversionofdoi:10.1038/nature14457en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449304/pdf/en
dash.licenseLAAen_US
dc.titleCoordinated regulation of bidirectional COPI transport at the Golgi by cdc42en
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNatureen
dash.depositing.authorYang, Jia-Shuen_US
dc.date.available2015-12-04T18:13:23Z
dc.identifier.doi10.1038/nature14457*
dash.contributor.affiliatedSchmider, Angela
dash.contributor.affiliatedSoberman, Roy
dash.contributor.affiliatedHsu, Victor
dash.contributor.affiliatedYang, Jia-Shu


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record