A direct GABAergic output from the basal ganglia to frontal cortex

DSpace/Manakin Repository

A direct GABAergic output from the basal ganglia to frontal cortex

Citable link to this page


Title: A direct GABAergic output from the basal ganglia to frontal cortex
Author: Saunders, Arpiar; Oldenburg, Ian A.; Berezovskii, Vladimir K.; Johnson, Caroline A.; Kingery, Nathan D.; Elliott, Hunter L.; Xie, Tiao; Gerfen, Charles R.; Sabatini, Bernardo L.

Note: Order does not necessarily reflect citation order of authors.

Citation: Saunders, Arpiar, Ian A. Oldenburg, Vladimir K. Berezovskii, Caroline A. Johnson, Nathan D. Kingery, Hunter L. Elliott, Tiao Xie, Charles R. Gerfen, and Bernardo L. Sabatini. 2014. “A direct GABAergic output from the basal ganglia to frontal cortex.” Nature 521 (7550): 85-89. doi:10.1038/nature14179. http://dx.doi.org/10.1038/nature14179.
Full Text & Related Files:
Abstract: The basal ganglia (BG) are phylogenetically conserved subcortical nuclei necessary for coordinated motor action and reward learning1. Current models postulate that the BG modulate cerebral cortex indirectly via an inhibitory output to thalamus, bidirectionally controlled by the BG via direct (dSPNs) and indirect (iSPNs) pathway striatal projection neurons2–4. The BG thalamic output sculpts cortical activity by interacting with signals from sensory and motor systems5. Here we describe a direct projection from the globus pallidus externus (GP), a central nucleus of the BG, to frontal regions of the cerebral cortex (FC). Two cell types make up the GP-FC projection, distinguished by their electrophysiological properties, cortical projections and expression of choline acetyltransferase (ChAT), a synthetic enzyme for the neurotransmitter acetylcholine (ACh). Despite these differences, ChAT+ cells, which have been historically identified as an extension of the nucleus basalis (NB), as well as ChAT− cells, release the inhibitory neurotransmitter GABA (γ-aminobutyric acid) and are inhibited by iSPNs and dSPNs of dorsal striatum. Thus GP-FC cells comprise a direct GABAergic/cholinergic projection under the control of striatum that activates frontal cortex in vivo. Furthermore, iSPN inhibition of GP-FC cells is sensitive to dopamine 2 receptor signaling, revealing a pathway by which drugs that target dopamine receptors for the treatment of neuropsychiatric disorders can act in the BG to modulate frontal cortices.
Published Version: doi:10.1038/nature14179
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425585/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:23845241
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)


Search DASH

Advanced Search