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dc.contributor.authorAbenza, Juan F.en_US
dc.contributor.authorCouturier, Etienneen_US
dc.contributor.authorDodgson, Jamesen_US
dc.contributor.authorDickmann, Johannaen_US
dc.contributor.authorChessel, Anatoleen_US
dc.contributor.authorDumais, Jacquesen_US
dc.contributor.authorSalas, Rafael E. Carazoen_US
dc.date.accessioned2015-12-04T18:15:07Z
dc.date.issued2015en_US
dc.identifier.citationAbenza, Juan F., Etienne Couturier, James Dodgson, Johanna Dickmann, Anatole Chessel, Jacques Dumais, and Rafael E. Carazo Salas. 2015. “Wall mechanics and exocytosis define the shape of growth domains in fission yeast.” Nature Communications 6 (1): 8400. doi:10.1038/ncomms9400. http://dx.doi.org/10.1038/ncomms9400.en
dc.identifier.issn2041-1723en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:23845329
dc.description.abstractThe amazing structural variety of cells is matched only by their functional diversity, and reflects the complex interplay between biochemical and mechanical regulation. How both regulatory layers generate specifically shaped cellular domains is not fully understood. Here, we report how cell growth domains are shaped in fission yeast. Based on quantitative analysis of cell wall expansion and elasticity, we develop a model for how mechanics and cell wall assembly interact and use it to look for factors underpinning growth domain morphogenesis. Surprisingly, we find that neither the global cell shape regulators Cdc42-Scd1-Scd2 nor the major cell wall synthesis regulators Bgs1-Bgs4-Rgf1 are reliable predictors of growth domain geometry. Instead, their geometry can be defined by cell wall mechanics and the cortical localization pattern of the exocytic factors Sec6-Syb1-Exo70. Forceful re-directioning of exocytic vesicle fusion to broader cortical areas induces proportional shape changes to growth domains, demonstrating that both features are causally linked.en
dc.language.isoen_USen
dc.publisherNature Pub. Groupen
dc.relation.isversionofdoi:10.1038/ncomms9400en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618311/pdf/en
dash.licenseLAAen_US
dc.titleWall mechanics and exocytosis define the shape of growth domains in fission yeasten
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNature Communicationsen
dc.date.available2015-12-04T18:15:07Z
dc.identifier.doi10.1038/ncomms9400*


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