dc.contributor.author | Mordukhovich, Irina | en_US |
dc.contributor.author | Coull, Brent | en_US |
dc.contributor.author | Kloog, Itai | en_US |
dc.contributor.author | Koutrakis, Petros | en_US |
dc.contributor.author | Vokonas, Pantel | en_US |
dc.contributor.author | Schwartz, Joel | en_US |
dc.date.accessioned | 2015-12-04T18:15:52Z | |
dc.date.issued | 2015 | en_US |
dc.identifier.citation | Mordukhovich, Irina, Brent Coull, Itai Kloog, Petros Koutrakis, Pantel Vokonas, and Joel Schwartz. 2015. “Exposure to sub-chronic and long-term particulate air pollution and heart rate variability in an elderly cohort: the Normative Aging Study.” Environmental Health 14 (1): 87. doi:10.1186/s12940-015-0074-z. http://dx.doi.org/10.1186/s12940-015-0074-z. | en |
dc.identifier.issn | 1476-069X | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:23845385 | |
dc.description.abstract | Background: Short-term particulate air pollution exposure is associated with reduced heart rate variability (HRV), a risk factor for cardiovascular morbidity and mortality, in many studies. Associations with sub-chronic or long-term exposures, however, have been sparsely investigated. We evaluated the effect of fine particulate matter (PM2.5) and black carbon (BC) exposures on HRV in an elderly cohort: the Normative Aging Study. Methods: We measured power in high frequency (HF) and low frequency (LF), standard deviation of normal-to-normal intervals (SDNN), and the LF:HF ratio among participants from the Greater Boston area. Residential BC exposures for 540 men (1161 study visits, 2000–2011) were estimated using a spatio-temporal land use regression model, and residential PM2.5 exposures for 475 men (992 visits, 2003–2011) were modeled using a hybrid satellite based and land-use model. We evaluated associations between moving averages of sub-chronic (3–84 day) and long-term (1 year) pollutant exposure estimates and HRV parameters using linear mixed models. Results: One-standard deviation increases in sub-chronic, but not long-term, BC were associated with reduced HF, LF, and SDNN and an increased LF:HF ratio (e.g., 28 day BC: −2.3 % HF [95 % CI:−4.6, −0.02]). Sub-chronic and long-term PM2.5 showed evidence of relations to an increased LF and LF:HF ratio (e.g., 1 year PM: 21.0 % LF:HF [8.6, 34.8]), but not to HF or SDNN, though the effect estimates were very imprecise and mostly spanned the null. Conclusions: We observed some evidence of a relation between longer-term BC and PM2.5 exposures and changes in HRV in an elderly cohort. While previous studies focused on short-term air pollution exposures, our results suggest that longer-term exposures may influence cardiac autonomic function. Electronic supplementary material The online version of this article (doi:10.1186/s12940-015-0074-z) contains supplementary material, which is available to authorized users. | en |
dc.language.iso | en_US | en |
dc.publisher | BioMed Central | en |
dc.relation.isversionof | doi:10.1186/s12940-015-0074-z | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636903/pdf/ | en |
dash.license | LAA | en_US |
dc.subject | Epidemiology | en |
dc.subject | Heart rate variability | en |
dc.subject | Air pollution | en |
dc.subject | Particulate matter | en |
dc.title | Exposure to sub-chronic and long-term particulate air pollution and heart rate variability in an elderly cohort: the Normative Aging Study | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | Environmental Health | en |
dash.depositing.author | Mordukhovich, Irina | en_US |
dc.date.available | 2015-12-04T18:15:52Z | |
dc.identifier.doi | 10.1186/s12940-015-0074-z | * |
dash.contributor.affiliated | Mordukhovich, Irina | |
dash.contributor.affiliated | Koutrakis, Petros | |
dash.contributor.affiliated | Coull, Brent | |
dash.contributor.affiliated | Schwartz, Joel | |
dc.identifier.orcid | 0000-0002-2557-150X | |