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dc.contributor.advisorRitter, Tobiasen_US
dc.contributor.authorHoover, Andrewen_US
dc.date.accessioned2015-12-04T18:41:15Z
dash.embargo.terms2016-11-01en_US
dc.date.created2015-11en_US
dc.date.issued2015-07-20en_US
dc.date.submitted2015en_US
dc.identifier.citationHoover, Andrew. 2015. A Transmetalation Reaction Enables the Synthesis of [18F]5-Fluorouracil From [18F]Fluoride for Human PET Imaging. Doctoral dissertation, Harvard University, Graduate School of Arts & Sciences.en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:23845408
dc.description.abstract5-Fluorouracil is a broad-spectrum chemotherapeutic for cancer treatment. [18F]5-Fluorouracil, which contains the radioactive isotope fluorine-18, is a tracer for positron emission tomography (PET) imaging and has been applied for determining the location over time of 5-fluorouracil in the bodies of human cancer patients. Potential applications of [18F]5-fluorouracil are for personalized chemotherapy and the development of new cancer treatments. All reported preparations of [18F]5-fluorouracil for human PET imaging have used [18F]F2 gas, which is challenging to produce and handle, and is less desired as a starting material in comparison to [18F]fluoride. This dissertation describes the development and translation of new chemical reactions to produce human doses of [18F]5-fluorouracil from [18F]fluoride. The first preparation of nickel(II) σ-aryl complexes by transmetalation from arylboronic acids was developed. This transmetalation reaction was applied to produce a nickel(II) σ-aryl complex that undergoes oxidative fluorination with [18F]fluoride for the synthesis of [18F]5-fluorouracil. This oxidative fluorination reaction was translated for production of human doses of [18F]5-fluorouracil. Although numerous transition metal-mediated fluorination reactions have been developed, none have previously been translated to enable human PET imaging.en_US
dc.description.sponsorshipChemistry and Chemical Biologyen_US
dc.format.mimetypeapplication/pdfen_US
dc.language.isoenen_US
dash.licenseLAAen_US
dc.subjectChemistry, Organicen_US
dc.titleA Transmetalation Reaction Enables the Synthesis of [18F]5-Fluorouracil From [18F]Fluoride for Human PET Imagingen_US
dc.typeThesis or Dissertationen_US
dash.depositing.authorHoover, Andrewen_US
dc.date.available2016-11-01T07:31:14Z
thesis.degree.date2015en_US
thesis.degree.grantorGraduate School of Arts & Sciencesen_US
thesis.degree.levelDoctoralen_US
thesis.degree.nameDoctor of Philosophyen_US
dc.contributor.committeeMemberMyers, Andrew G.en_US
dc.contributor.committeeMemberBetley, Theodore A.en_US
dc.type.materialtexten_US
thesis.degree.departmentChemistry and Chemical Biologyen_US
dash.identifier.vireohttp://etds.lib.harvard.edu/gsas/admin/view/573en_US
dc.description.keywordsTransmetalation; Nickel; Fluorine-18; [18F]; 5-Fluorouracil; PET; Imagingen_US
dash.author.emailhoov.a.j@gmail.comen_US
dash.identifier.drsurn-3:HUL.DRS.OBJECT:25142571en_US
dash.contributor.affiliatedHoover, Andrew


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