Fine-mapping in the MHC region accounts for 18% additional genetic risk for celiac disease

 
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Gutierrez-Achury, Javier
Zhernakova, Alexandra
Pulit, Sara L.
Trynka, Gosia
Hunt, Karen A.
Romanos, Jihane
van Heel, David A.
Wijmenga, Cisca
de Bakker, Paul I.W.
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https://doi.org/10.1038/ng.3268
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Gutierrez-Achury, Javier, Alexandra Zhernakova, Sara L. Pulit, Gosia Trynka, Karen A. Hunt, Jihane Romanos, Soumya Raychaudhuri, David A. van Heel, Cisca Wijmenga, and Paul I.W. de Bakker. 2015. “Fine-mapping in the MHC region accounts for 18% additional genetic risk for celiac disease.” Nature genetics 47 (6): 577-578. doi:10.1038/ng.3268. http://dx.doi.org/10.1038/ng.3268.
Abstract
Although dietary gluten is the trigger, celiac disease risk is strongly influenced by genetic variation in the major histocompatibility complex (MHC) region. We fine-mapped the MHC association signal to identify additional risk factors independent of the HLA-DQ alleles and observed five novel associations that account for 18% of the genetic risk. Together with the 57 known non-MHC loci, genetic variation can now explain up to 48% of celiac disease heritability.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449296/pdf/
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http://nrs.harvard.edu/urn-3:HUL.InstRepos:23993472

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