Therapeutic Implications for Overcoming Radiation Resistance in Cancer Therapy

DSpace/Manakin Repository

Therapeutic Implications for Overcoming Radiation Resistance in Cancer Therapy

Citable link to this page

 

 
Title: Therapeutic Implications for Overcoming Radiation Resistance in Cancer Therapy
Author: Kim, Byeong Mo; Hong, Yunkyung; Lee, Seunghoon; Liu, Pengda; Lim, Ji Hong; Lee, Yong Heon; Lee, Tae Ho; Chang, Kyu Tae; Hong, Yonggeun

Note: Order does not necessarily reflect citation order of authors.

Citation: Kim, Byeong Mo, Yunkyung Hong, Seunghoon Lee, Pengda Liu, Ji Hong Lim, Yong Heon Lee, Tae Ho Lee, Kyu Tae Chang, and Yonggeun Hong. 2015. “Therapeutic Implications for Overcoming Radiation Resistance in Cancer Therapy.” International Journal of Molecular Sciences 16 (11): 26880-26913. doi:10.3390/ijms161125991. http://dx.doi.org/10.3390/ijms161125991.
Full Text & Related Files:
Abstract: Ionizing radiation (IR), such as X-rays and gamma (γ)-rays, mediates various forms of cancer cell death such as apoptosis, necrosis, autophagy, mitotic catastrophe, and senescence. Among them, apoptosis and mitotic catastrophe are the main mechanisms of IR action. DNA damage and genomic instability contribute to IR-induced cancer cell death. Although IR therapy may be curative in a number of cancer types, the resistance of cancer cells to radiation remains a major therapeutic problem. In this review, we describe the morphological and molecular aspects of various IR-induced types of cell death. We also discuss cytogenetic variations representative of IR-induced DNA damage and genomic instability. Most importantly, we focus on several pathways and their associated marker proteins responsible for cancer resistance and its therapeutic implications in terms of cancer cell death of various types and characteristics. Finally, we propose radiation-sensitization strategies, such as the modification of fractionation, inflammation, and hypoxia and the combined treatment, that can counteract the resistance of tumors to IR.
Published Version: doi:10.3390/ijms161125991
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661850/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:23993514
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters