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dc.contributor.authorJin, Duoen_US
dc.contributor.authorLiu, Yuanyuanen_US
dc.contributor.authorSun, Fangen_US
dc.contributor.authorWang, Xuhuaen_US
dc.contributor.authorLiu, Xuefengen_US
dc.contributor.authorHe, Zhigangen_US
dc.date.accessioned2016-01-04T19:23:24Z
dc.date.issued2015en_US
dc.identifier.citationJin, Duo, Yuanyuan Liu, Fang Sun, Xuhua Wang, Xuefeng Liu, and Zhigang He. 2015. “Restoration of skilled locomotion by sprouting corticospinal axons induced by co-deletion of PTEN and SOCS3.” Nature Communications 6 (1): 8074. doi:10.1038/ncomms9074. http://dx.doi.org/10.1038/ncomms9074.en
dc.identifier.issn2041-1723en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:23993534
dc.description.abstractThe limited rewiring of the corticospinal tract (CST) only partially compensates the lost functions after stroke, brain trauma and spinal cord injury. Therefore it is important to develop new therapies to enhance the compensatory circuitry mediated by spared CST axons. Here by using a unilateral pyramidotomy model, we find that deletion of cortical suppressor of cytokine signaling 3 (SOCS3), a negative regulator of cytokine-activated pathway, promotes sprouting of uninjured CST axons to the denervated spinal cord. A likely trigger of such sprouting is ciliary neurotrophic factor (CNTF) expressed in local spinal neurons. Such sprouting can be further enhanced by deletion of phosphatase and tensin homolog (PTEN), a mechanistic target of rapamycin (mTOR) negative regulator, resulting in significant recovery of skilled locomotion. Ablation of the corticospinal neurons with sprouting axons abolishes the improved behavioural performance. Furthermore, by optogenetics-based specific CST stimulation, we show a direct limb motor control by sprouting CST axons, providing direct evidence for the reformation of a functional circuit.en
dc.language.isoen_USen
dc.publisherNature Pub. Groupen
dc.relation.isversionofdoi:10.1038/ncomms9074en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662086/pdf/en
dash.licenseLAAen_US
dc.titleRestoration of skilled locomotion by sprouting corticospinal axons induced by co-deletion of PTEN and SOCS3en
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNature Communicationsen
dash.depositing.authorLiu, Yuanyuanen_US
dc.date.available2016-01-04T19:23:24Z
dc.identifier.doi10.1038/ncomms9074*
dash.authorsorderedfalse
dash.contributor.affiliatedLiu, Yuanyuan
dash.contributor.affiliatedWang, Xuhua
dash.contributor.affiliatedHe, Zhigang
dash.contributor.affiliatedLiu, Xuefeng


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