NADH oxidase-dependent CD39 expression by CD8+ T cells modulates interferon gamma responses via generation of adenosine

DSpace/Manakin Repository

NADH oxidase-dependent CD39 expression by CD8+ T cells modulates interferon gamma responses via generation of adenosine

Citable link to this page

 

 
Title: NADH oxidase-dependent CD39 expression by CD8+ T cells modulates interferon gamma responses via generation of adenosine
Author: Bai, Aiping; Moss, Alan; Rothweiler, Sonja; Serena Longhi, Maria; Wu, Yan; Junger, Wolfgang G.; Robson, Simon C.

Note: Order does not necessarily reflect citation order of authors.

Citation: Bai, Aiping, Alan Moss, Sonja Rothweiler, Maria Serena Longhi, Yan Wu, Wolfgang G. Junger, and Simon C. Robson. 2015. “NADH oxidase-dependent CD39 expression by CD8+ T cells modulates interferon gamma responses via generation of adenosine.” Nature Communications 6 (1): 8819. doi:10.1038/ncomms9819. http://dx.doi.org/10.1038/ncomms9819.
Full Text & Related Files:
Abstract: Interferon gamma (IFNγ)-producing CD8+ T cells (Tc1) play important roles in immunological disease. We now report that CD3/CD28-mediated stimulation of CD8+ T cells to generate Tc1 cells, not only increases IFNγ production but also boosts the generation of reactive oxygen species (ROS) and augments expression of CD39. Inhibition of NADPH oxidases or knockdown of gp91phox in CD8+ T cells abrogates ROS generation, which in turn modulates JNK and NFκB signalling with decreases in both IFNγ levels and CD39 expression. CD39+CD8+ T cells substantially inhibit IFNγ production by CD39−CD8+ T cells via the paracrine generation of adenosine, which is operational via adenosine type 2A receptors. Increases in numbers of CD39+CD8+ T cells and associated enhancements in ROS signal transduction are noted in cells from patients with Crohn's disease. Our findings provide insights into Tc1-mediated IFNγ responses and ROS generation and link these pathways to CD39/adenosine-mediated effects in immunological disease.
Published Version: doi:10.1038/ncomms9819
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667632/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:23993551
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters