The transcriptome and miRNome profiling of glioblastoma tissues and peritumoral regions highlights molecular pathways shared by tumors and surrounding areas and reveals differences between short-term and long-term survivors

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The transcriptome and miRNome profiling of glioblastoma tissues and peritumoral regions highlights molecular pathways shared by tumors and surrounding areas and reveals differences between short-term and long-term survivors

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dc.contributor.author Fazi, Barbara en_US
dc.contributor.author Felsani, Armando en_US
dc.contributor.author Grassi, Luigi en_US
dc.contributor.author Moles, Anna en_US
dc.contributor.author D'Andrea, Daniel en_US
dc.contributor.author Toschi, Nicola en_US
dc.contributor.author Sicari, Daria en_US
dc.contributor.author De Bonis, Pasquale en_US
dc.contributor.author Anile, Carmelo en_US
dc.contributor.author Guerrisi, Maria Giovanna en_US
dc.contributor.author Luca, Emilia en_US
dc.contributor.author Farace, Maria Giulia en_US
dc.contributor.author Maira, Giulio en_US
dc.contributor.author Ciafré, Silvia Anna en_US
dc.contributor.author Mangiola, Annunziato en_US
dc.date.accessioned 2016-01-04T19:23:47Z
dc.date.issued 2015 en_US
dc.identifier.citation Fazi, B., A. Felsani, L. Grassi, A. Moles, D. D'Andrea, N. Toschi, D. Sicari, et al. 2015. “The transcriptome and miRNome profiling of glioblastoma tissues and peritumoral regions highlights molecular pathways shared by tumors and surrounding areas and reveals differences between short-term and long-term survivors.” Oncotarget 6 (26): 22526-22552. en
dc.identifier.issn 1949-2553 en
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:23993598
dc.description.abstract Glioblastoma multiforme (GBM) is the most common and deadliest primary brain tumor, driving patients to death within 15 months after diagnosis (short term survivors, ST), with the exception of a small fraction of patients (long term survivors, LT) surviving longer than 36 months. Here we present deep sequencing data showing that peritumoral (P) areas differ from healthy white matter, but share with their respective frankly tumoral (C) samples, a number of mRNAs and microRNAs representative of extracellular matrix remodeling, TGFβ and signaling, of the involvement of cell types different from tumor cells but contributing to tumor growth, such as microglia or reactive astrocytes. Moreover, we provide evidence about RNAs differentially expressed in ST vs LT samples, suggesting the contribution of TGF-β signaling in this distinction too. We also show that the edited form of miR-376c-3p is reduced in C vs P samples and in ST tumors compared to LT ones. As a whole, our study provides new insights into the still puzzling distinction between ST and LT tumors, and sheds new light onto that “grey” zone represented by the area surrounding the tumor, which we show to be characterized by the expression of several molecules shared with the proper tumor mass. en
dc.language.iso en_US en
dc.publisher Impact Journals LLC en
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673180/pdf/ en
dash.license LAA en_US
dc.subject glioblastoma en
dc.subject microRNA en
dc.subject TGFβ en
dc.subject peritumoral area en
dc.subject editing en
dc.title The transcriptome and miRNome profiling of glioblastoma tissues and peritumoral regions highlights molecular pathways shared by tumors and surrounding areas and reveals differences between short-term and long-term survivors en
dc.type Journal Article en_US
dc.description.version Version of Record en
dc.relation.journal Oncotarget en
dc.date.available 2016-01-04T19:23:47Z

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