A Comparative Study of Tests for Homogeneity of Variances with Application to DNA Methylation Data

DSpace/Manakin Repository

A Comparative Study of Tests for Homogeneity of Variances with Application to DNA Methylation Data

Citable link to this page

 

 
Title: A Comparative Study of Tests for Homogeneity of Variances with Application to DNA Methylation Data
Author: Li, Xuan; Qiu, Weiliang; Morrow, Jarrett; DeMeo, Dawn L.; Weiss, Scott T.; Fu, Yuejiao; Wang, Xiaogang

Note: Order does not necessarily reflect citation order of authors.

Citation: Li, Xuan, Weiliang Qiu, Jarrett Morrow, Dawn L. DeMeo, Scott T. Weiss, Yuejiao Fu, and Xiaogang Wang. 2015. “A Comparative Study of Tests for Homogeneity of Variances with Application to DNA Methylation Data.” PLoS ONE 10 (12): e0145295. doi:10.1371/journal.pone.0145295. http://dx.doi.org/10.1371/journal.pone.0145295.
Full Text & Related Files:
Abstract: Variable DNA methylation has been associated with cancers and complex diseases. Researchers have identified many DNA methylation markers that have different mean methylation levels between diseased subjects and normal subjects. Recently, researchers found that DNA methylation markers with different variabilities between subject groups could also have biological meaning. In this article, we aimed to help researchers choose the right test of equal variance in DNA methylation data analysis. We performed systematic simulation studies and a real data analysis to compare the performances of 7 equal-variance tests, including 2 tests recently proposed in the DNA methylation analysis literature. Our results showed that the Brown-Forsythe test and trimmed-mean-based Levene's test had good performance in testing for equality of variance in our simulation studies and real data analyses. Our results also showed that outlier profiles could be biologically very important.
Published Version: doi:10.1371/journal.pone.0145295
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684215/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:23993705
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters