Three-dimensional macroporous nanoelectronic networks as minimally invasive brain probes

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Three-dimensional macroporous nanoelectronic networks as minimally invasive brain probes

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dc.contributor.author Xie, Chong
dc.contributor.author Liu, Jia
dc.contributor.author Fu, Tian-Ming
dc.contributor.author Dai, Xiaochuan
dc.contributor.author Zhou, Wei
dc.contributor.author Lieber, Charles M.
dc.date.accessioned 2016-01-29T21:09:42Z
dash.embargo.terms 2016-04-06
dc.date.issued 2015
dc.identifier Quick submit: 2015-10-05T16:26:30-04:00
dc.identifier.citation Xie, Chong, Jia Liu, Tian-Ming Fu, Xiaochuan Dai, Wei Zhou, and Charles M. Lieber. 2015. “Three-Dimensional Macroporous Nanoelectronic Networks as Minimally Invasive Brain Probes.” Nat Mater 14 (12) (October 5): 1286–1292. doi:10.1038/nmat4427. en_US
dc.identifier.issn 1476-1122 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:24981602
dc.description.abstract Direct electrical recording and stimulation of neural activity using micro-fabricated silicon and metal micro-wire probes have contributed extensively to basic neuroscience and therapeutic applications; however, the dimensional and mechanical mismatch of these probes with the brain tissue limits their stability in chronic implants and decreases the neuron–device contact. Here, we demonstrate the realization of a three-dimensional macroporous nanoelectronic brain probe that combines ultra-flexibility and subcellular feature sizes to overcome these limitations. Built-in strains controlling the local geometry of the macroporous devices are designed to optimize the neuron/probe interface and to promote integration with the brain tissue while introducing minimal mechanical perturbation. The ultra-flexible probes were implanted frozen into rodent brains and used to record multiplexed local field potentials and single-unit action potentials from the somatosensory cortex. Significantly, histology analysis revealed filling-in of neural tissue through the macroporous network and attractive neuron–probe interactions, consistent with long-term biocompatibility of the device. en_US
dc.description.sponsorship Chemistry and Chemical Biology en_US
dc.language.iso en_US en_US
dc.publisher Nature Publishing Group en_US
dc.relation.isversionof doi:10.1038/nmat4427 en_US
dash.license LAA
dc.title Three-dimensional macroporous nanoelectronic networks as minimally invasive brain probes en_US
dc.type Journal Article en_US
dc.date.updated 2015-10-05T20:26:32Z
dc.description.version Accepted Manuscript en_US
dc.rights.holder Chong Xie, Jia Liu, Tian-Ming Fu, Xiaochuan Dai, Wei Zhou and Charles M. Lieber
dc.relation.journal Nature Materials en_US
dash.depositing.author Lieber, Charles M.
dash.waiver 2015-08-17
dc.date.available 2016-04-06T07:30:56Z
dc.identifier.orcid ORCID  0000-0002-1876-8558 en_US

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