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dc.contributor.authorXie, Chong
dc.contributor.authorLiu, Jia
dc.contributor.authorFu, Tian-Ming
dc.contributor.authorDai, Xiaochuan
dc.contributor.authorZhou, Wei
dc.contributor.authorLieber, Charles M.
dc.date.accessioned2016-01-29T21:09:42Z
dash.embargo.terms2016-04-06
dc.date.issued2015
dc.identifierQuick submit: 2015-10-05T16:26:30-04:00
dc.identifier.citationXie, Chong, Jia Liu, Tian-Ming Fu, Xiaochuan Dai, Wei Zhou, and Charles M. Lieber. 2015. “Three-Dimensional Macroporous Nanoelectronic Networks as Minimally Invasive Brain Probes.” Nat Mater 14 (12) (October 5): 1286–1292. doi:10.1038/nmat4427.en_US
dc.identifier.issn1476-1122en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:24981602
dc.description.abstractDirect electrical recording and stimulation of neural activity using micro-fabricated silicon and metal micro-wire probes have contributed extensively to basic neuroscience and therapeutic applications; however, the dimensional and mechanical mismatch of these probes with the brain tissue limits their stability in chronic implants and decreases the neuron–device contact. Here, we demonstrate the realization of a three-dimensional macroporous nanoelectronic brain probe that combines ultra-flexibility and subcellular feature sizes to overcome these limitations. Built-in strains controlling the local geometry of the macroporous devices are designed to optimize the neuron/probe interface and to promote integration with the brain tissue while introducing minimal mechanical perturbation. The ultra-flexible probes were implanted frozen into rodent brains and used to record multiplexed local field potentials and single-unit action potentials from the somatosensory cortex. Significantly, histology analysis revealed filling-in of neural tissue through the macroporous network and attractive neuron–probe interactions, consistent with long-term biocompatibility of the device.en_US
dc.description.sponsorshipChemistry and Chemical Biologyen_US
dc.language.isoen_USen_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofdoi:10.1038/nmat4427en_US
dash.licenseLAA
dc.titleThree-dimensional macroporous nanoelectronic networks as minimally invasive brain probesen_US
dc.typeJournal Articleen_US
dc.date.updated2015-10-05T20:26:32Z
dc.description.versionAccepted Manuscripten_US
dc.rights.holderChong Xie, Jia Liu, Tian-Ming Fu, Xiaochuan Dai, Wei Zhou and Charles M. Lieber
dc.relation.journalNature Materialsen_US
dash.depositing.authorLieber, Charles M.
dash.waiver2015-08-17
dc.date.available2016-04-06T07:30:56Z
dc.identifier.doi10.1038/nmat4427*
dash.identifier.orcid0000-0002-1876-8558en_US
dash.contributor.affiliatedLiu, Jia
dash.contributor.affiliatedFu, Tian-Ming
dash.contributor.affiliatedXie, Chong
dash.contributor.affiliatedZhou, Wei
dash.contributor.affiliatedDai, Xiaochuan
dash.contributor.affiliatedLieber, Charles
dc.identifier.orcid0000-0002-5628-8889
dc.identifier.orcid0000-0002-1876-8558


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