DICER1 and microRNA regulation in post-traumatic stress disorder with comorbid depression

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DICER1 and microRNA regulation in post-traumatic stress disorder with comorbid depression

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Title: DICER1 and microRNA regulation in post-traumatic stress disorder with comorbid depression
Author: Wingo, Aliza P.; Almli, Lynn M.; Stevens, Jennifer J.; Klengel, Torsten; Uddin, Monica; Li, Yujing; Bustamante, Angela C.; Lori, Adriana; Koen, Nastassja; Stein, Dan J.; Smith, Alicia K.; Aiello, Allison E.; Koenen, Karestan C.; Wildman, Derek E.; Galea, Sandro; Bradley, Bekh; Binder, Elisabeth B.; Jin, Peng; Gibson, Greg; Ressler, Kerry J.

Note: Order does not necessarily reflect citation order of authors.

Citation: Wingo, A. P., L. M. Almli, J. J. Stevens, T. Klengel, M. Uddin, Y. Li, A. C. Bustamante, et al. 2015. “DICER1 and microRNA regulation in post-traumatic stress disorder with comorbid depression.” Nature Communications 6 (1): 10106. doi:10.1038/ncomms10106. http://dx.doi.org/10.1038/ncomms10106.
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Abstract: DICER1 is an enzyme that generates mature microRNAs (miRNAs), which regulate gene expression post-transcriptionally in brain and other tissues and is involved in synaptic maturation and plasticity. Here, through genome-wide differential gene expression survey of post-traumatic stress disorder (PTSD) with comorbid depression (PTSD&Dep), we find that blood DICER1 expression is significantly reduced in cases versus controls, and replicate this in two independent cohorts. Our follow-up studies find that lower blood DICER1 expression is significantly associated with increased amygdala activation to fearful stimuli, a neural correlate for PTSD. Additionally, a genetic variant in the 3′ un-translated region of DICER1, rs10144436, is significantly associated with DICER1 expression and with PTSD&Dep, and the latter is replicated in an independent cohort. Furthermore, genome-wide differential expression survey of miRNAs in blood in PTSD&Dep reveals miRNAs to be significantly downregulated in cases versus controls. Together, our novel data suggest DICER1 plays a role in molecular mechanisms of PTSD&Dep through the DICER1 and the miRNA regulation pathway.
Published Version: doi:10.1038/ncomms10106
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686835/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:24983917
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