Clinicopathological characterisation of small (2 cm or less) proximal and distal gastric carcinomas in a Chinese population

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Clinicopathological characterisation of small (2 cm or less) proximal and distal gastric carcinomas in a Chinese population

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Title: Clinicopathological characterisation of small (2 cm or less) proximal and distal gastric carcinomas in a Chinese population
Author: Huang, Qin; Shi, Jiong; Sun, Qi; Gold, Jason S.; Chen, Jieyu; Wu, Hongyan; Yu, Huiping; Zhang, Yifen; Mashimo, Hiroshi; Yu, Chenggong; Manasco, Travis; Guan, Wenyan; Lauwers, Gregory Y.

Note: Order does not necessarily reflect citation order of authors.

Citation: Huang, Q., J. Shi, Q. Sun, J. S. Gold, J. Chen, H. Wu, H. Yu, et al. 2015. “Clinicopathological characterisation of small (2 cm or less) proximal and distal gastric carcinomas in a Chinese population.” Pathology 47 (6): 526-532. doi:10.1097/PAT.0000000000000276. http://dx.doi.org/10.1097/PAT.0000000000000276.
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Abstract: SummaryClinicopathological characteristics of small gastric carcinoma have not been well defined in Chinese patients. The aim of this study was to investigate and compare small proximal (PGC, n = 111) with distal (DGC, n = 202) gastric carcinoma in 313 consecutive surgically resected small (≤2 cm) gastric carcinomas diagnosed with the WHO criteria. PGC patients were significantly older (average age 63 years versus 59 in DGCs) with a male/female ratio of 3:1. Most tumours were clustered along the lesser curvature (74% in PGCs and 65% in DGCs). Compared to DGCs, PGCs showed a protruded gross pattern significantly more frequently and were significantly better differentiated with a significantly wider histomorphological spectrum. Surprisingly, PGCs were composed of significantly fewer signet-ring cell carcinomas (1% versus 16% in DGCs) but were significantly more deeply invasive, compared to DGCs. Lymph node metastasis was detected in 23% overall, but was significantly less frequent in PGCs (16%) than in DGCs (26%) (p < 0.05). However, the difference in survival between the two groups was not statistically significant. Our results demonstrate that in Chinese patients, PGCs display distinct clinicopathological characteristics, compared to DGCs.
Published Version: doi:10.1097/PAT.0000000000000276
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699347/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:24983924
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