Clinicopathological characterisation of small (2 cm or less) proximal and distal gastric carcinomas in a Chinese population
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CitationHuang, Q., J. Shi, Q. Sun, J. S. Gold, J. Chen, H. Wu, H. Yu, et al. 2015. “Clinicopathological characterisation of small (2 cm or less) proximal and distal gastric carcinomas in a Chinese population.” Pathology 47 (6): 526-532. doi:10.1097/PAT.0000000000000276. http://dx.doi.org/10.1097/PAT.0000000000000276.
AbstractSummaryClinicopathological characteristics of small gastric carcinoma have not been well defined in Chinese patients. The aim of this study was to investigate and compare small proximal (PGC, n = 111) with distal (DGC, n = 202) gastric carcinoma in 313 consecutive surgically resected small (≤2 cm) gastric carcinomas diagnosed with the WHO criteria. PGC patients were significantly older (average age 63 years versus 59 in DGCs) with a male/female ratio of 3:1. Most tumours were clustered along the lesser curvature (74% in PGCs and 65% in DGCs). Compared to DGCs, PGCs showed a protruded gross pattern significantly more frequently and were significantly better differentiated with a significantly wider histomorphological spectrum. Surprisingly, PGCs were composed of significantly fewer signet-ring cell carcinomas (1% versus 16% in DGCs) but were significantly more deeply invasive, compared to DGCs. Lymph node metastasis was detected in 23% overall, but was significantly less frequent in PGCs (16%) than in DGCs (26%) (p < 0.05). However, the difference in survival between the two groups was not statistically significant. Our results demonstrate that in Chinese patients, PGCs display distinct clinicopathological characteristics, compared to DGCs.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:24983924
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