From the Bench to the Field in Low-Cost Diagnostics: Two Case Studies

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From the Bench to the Field in Low-Cost Diagnostics: Two Case Studies

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Title: From the Bench to the Field in Low-Cost Diagnostics: Two Case Studies
Author: Kumar, Ashok Ashwin; Hennek, Jonathan; Smith, Barbara L; Kumar, Shailendra; Beattie, Patrick; Jain, Sidhartha; Rolland, Jason P.; Stossel, Thomas Peter; Chunda-Liyoka, Catherine; Whitesides, George McClelland

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Citation: Kumar, Ashok A., Jonathan W. Hennek, Barbara S. Smith, Shailendra Kumar, Patrick Beattie, Sidhartha Jain, Jason P. Rolland, Thomas P. Stossel, Catherine Chunda-Liyoka, and George M. Whitesides. 2015. “From the Bench to the Field in Low-Cost Diagnostics: Two Case Studies.” Angew. Chem. Int. Ed. 54 (20) (April 27): 5836–5853. doi:10.1002/anie.201411741.
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Abstract: Despite the growth of research in universities on point-of-care (POC) diagnostics for global health, most devices never leave the laboratory. The processes that move diagnostic technology from the laboratory to the field—the processes intended to evaluate operation and performance under realistic conditions—are more complicated than they might seem. Two case studies illustrate this process: the development of a paper-based device to measure liver function, and the development of a device to identify sickle cell disease based on aqueous multiphase systems (AMPS) and differences in the densities of normal and sickled cells. Details of developing these devices provide strategies for forming partnerships, prototyping devices, designing studies, and evaluating POC diagnostics. Technical and procedural lessons drawn from these experiences may be useful to those designing diagnostic tests for developing countries, and more generally, technologies for use in resource-limited environments.
Published Version: doi:10.1002/anie.201411741
Terms of Use: This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAP
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:25045709
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