No coexistence for free: Neutral null models for multistrain pathogens
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CitationLipsitch, Marc, Caroline Colijn, Ted Cohen, William P. Hanage, and Christophe Fraser. 2009. “No Coexistence for Free: Neutral Null Models for Multistrain Pathogens.” Epidemics 1 (1) (March): 2–13. doi:10.1016/j.epidem.2008.07.001.
AbstractIn most pathogens, multiple strains are maintained within host populations. Quantifying the mechanisms underlying strain coexistence would aid public health planning and improve understanding of disease dynamics. We argue that mathematical models of strain coexistence, when applied to indistinguishable strains, should meet criteria for both ecological neutrality and population genetic neutrality. We show that closed clonal transmission models which can be written in an “ancestor-tracing” form that meets the former criterion will also satisfy the latter. Neutral models can be a parsimonious starting point for studying mechanisms of strain coexistence; implications for past and future studies are discussed.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:25124591
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