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dc.contributor.authorMoore, Talia Yuki
dc.contributor.authorOrgan, Chris
dc.contributor.authorEdwards, Scott V.
dc.contributor.authorBiewener, Andrew Austin
dc.contributor.authorTabin, Clifford James
dc.contributor.authorFarish, Jenkins
dc.contributor.authorCooper, Kimberly
dc.date.accessioned2016-02-25T19:17:36Z
dc.date.issued2015
dc.identifierQuick submit: 2016-01-20T15:42:59-05:00
dc.identifier.citationMoore, Talia Y., Chris L. Organ, Scott V. Edwards, Andrew A. Biewener, Clifford J. Tabin, Farish A. Jenkins, and Kimberly L. Cooper. 2015. “Multiple Phylogenetically Distinct Events Shaped the Evolution of Limb Skeletal Morphologies Associated with Bipedalism in the Jerboas.” Current Biology 25 (21) (November): 2785–2794. doi:10.1016/j.cub.2015.09.037.en_US
dc.identifier.issn0960-9822en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:25620509
dc.description.abstractRecent rapid advances in experimental biology have expanded the opportunity for interdisciplinary investigations of the evolution of form and function in non-traditional model species. However, historical divisions of philosophy and methodology between evolutionary/organismal biologists and developmental geneticists often preclude an effective merging of disciplines. In an effort to overcome these divisions, we take advantage of the extraordinary morphological diversity of the rodent superfamily Dipodoidea, including the bipedal jerboas, to experimentally study the developmental mechanisms and biomechanical performance of a remarkably divergent limb structure. Here, we place multiple limb character states in a locomotor and phylogenetic context. Whereas obligate bipedalism arose just once in the ancestor of extant jerboas, we find that digit loss, metatarsal fusion, between-limb proportions, and within-hindlimb proportions all evolved independently of one another. Digit loss occurred three times through at least two distinct developmental mechanisms, and elongation of the hindlimb relative to the forelimb is not simply due to growth mechanisms that change proportions within the hindlimb. Furthermore, we find strong evidence for punctuated evolution of allometric scaling of hindlimb elements during the radiation of Dipodoidea. Our work demonstrates the value of leveraging the evolutionary history of a clade to establish criteria for identifying the developmental genetic mechanisms of morphological diversification.en_US
dc.description.sponsorshipOrganismic and Evolutionary Biologyen_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dc.relation.isversionofdoi:10.1016/j.cub.2015.09.037en_US
dash.licenseOAP
dc.titleMultiple Phylogenetically Distinct Events Shaped the Evolution of Limb Skeletal Morphologies Associated with Bipedalism in the Jerboasen_US
dc.typeJournal Articleen_US
dc.date.updated2016-01-20T20:43:00Z
dc.description.versionAccepted Manuscripten_US
dc.rights.holderTalia Y. Moore, Chris L. Organ, Scott V. Edwards, Andrew A. Biewener, Clifford J. Tabin, Farish A. Jenkins Jr., Kimberly L. Cooper
dc.relation.journalCurrent Biologyen_US
dash.depositing.authorBiewener, Andrew Austin
dc.date.available2016-02-25T19:17:36Z
dc.identifier.doi10.1016/j.cub.2015.09.037*
dash.contributor.affiliatedOrgan, Chris
dash.contributor.affiliatedTabin, Clifford
dash.contributor.affiliatedMoore, Talia Yuki
dash.contributor.affiliatedEdwards, Scott
dash.contributor.affiliatedBiewener, Andrew
dc.identifier.orcid0000-0003-0867-4512


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