LLT1 and CD161 Expression in Human Germinal Centers Promotes B Cell Activation and CXCR4 Downregulation

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LLT1 and CD161 Expression in Human Germinal Centers Promotes B Cell Activation and CXCR4 Downregulation

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Title: LLT1 and CD161 Expression in Human Germinal Centers Promotes B Cell Activation and CXCR4 Downregulation
Author: Llibre, Alba; López-Macías, Constantino; Marafioti, Teresa; Mehta, Hema; Partridge, Amy; Kanzig, Carina; Rivellese, Felice; Galson, Jacob D.; Walker, Lucy J.; Milne, Paul; Phillips, Rodney E.; Kelly, Dominic F.; Freeman, Gordon J.; El Shikh, Mohey Eldin; Klenerman, Paul; Willberg, Christian B.

Note: Order does not necessarily reflect citation order of authors.

Citation: Llibre, A., C. López-Macías, T. Marafioti, H. Mehta, A. Partridge, C. Kanzig, F. Rivellese, et al. 2016. “LLT1 and CD161 Expression in Human Germinal Centers Promotes B Cell Activation and CXCR4 Downregulation.” The Journal of Immunology Author Choice 196 (5): 2085-2094. doi:10.4049/jimmunol.1502462. http://dx.doi.org/10.4049/jimmunol.1502462.
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Abstract: Germinal centers (GCs) are microanatomical structures critical for the development of high-affinity Abs and B cell memory. They are organized into two zones, light and dark, with coordinated roles, controlled by local signaling. The innate lectin-like transcript 1 (LLT1) is known to be expressed on B cells, but its functional role in the GC reaction has not been explored. In this study, we report high expression of LLT1 on GC-associated B cells, early plasmablasts, and GC-derived lymphomas. LLT1 expression was readily induced via BCR, CD40, and CpG stimulation on B cells. Unexpectedly, we found high expression of the LLT1 ligand, CD161, on follicular dendritic cells. Triggering of LLT1 supported B cell activation, CD83 upregulation, and CXCR4 downregulation. Overall, these data suggest that LLT1–CD161 interactions play a novel and important role in B cell maturation within the GC in humans.
Published Version: doi:10.4049/jimmunol.1502462
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760235/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:25658379
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