Oxygenation to improve cancer vaccines, adoptive cell transfer and blockade of immunological negative regulators

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Oxygenation to improve cancer vaccines, adoptive cell transfer and blockade of immunological negative regulators

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Title: Oxygenation to improve cancer vaccines, adoptive cell transfer and blockade of immunological negative regulators
Author: Hatfield, Stephen M; Sitkovsky, Michail

Note: Order does not necessarily reflect citation order of authors.

Citation: Hatfield, Stephen M., and Michail Sitkovsky. 2015. “Oxygenation to improve cancer vaccines, adoptive cell transfer and blockade of immunological negative regulators.” Oncoimmunology 4 (12): e1052934. doi:10.1080/2162402X.2015.1052934. http://dx.doi.org/10.1080/2162402X.2015.1052934.
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Abstract: Oxygenation of tumors weakens the tumor-protecting immunosuppressive signaling by A2A adenosine receptors in hypoxic and extracellular adenosine-rich microenvironments. This, in turn, unleashes the otherwise inhibited tumor-reactive T and natural killer (NK) cells. Oxygenation of tumors thus emerges as a novel checkpoint inhibitor of potential therapeutic value, but only in combination with cancer immunotherapies.
Published Version: doi:10.1080/2162402X.2015.1052934
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635883/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:25658394
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