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dc.contributor.authorSinghal, Garimaen_US
dc.contributor.authorFisher, ffolliott Martinen_US
dc.contributor.authorChee, Melissa J.en_US
dc.contributor.authorTan, Tze Guanen_US
dc.contributor.authorEl Ouaamari, Abdelfattahen_US
dc.contributor.authorAdams, Andrew C.en_US
dc.contributor.authorNajarian, Roberten_US
dc.contributor.authorKulkarni, Rohit N.en_US
dc.contributor.authorBenoist, Christopheen_US
dc.contributor.authorFlier, Jeffrey S.en_US
dc.contributor.authorMaratos-Flier, Eleftheriaen_US
dc.date.accessioned2016-03-01T19:49:20Z
dc.date.issued2016en_US
dc.identifier.citationSinghal, G., f. M. Fisher, M. J. Chee, T. G. Tan, A. El Ouaamari, A. C. Adams, R. Najarian, et al. 2016. “Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas.” PLoS ONE 11 (2): e0148252. doi:10.1371/journal.pone.0148252. http://dx.doi.org/10.1371/journal.pone.0148252.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:25658409
dc.description.abstractFibroblast growth factor 21 (FGF21) is an important endocrine metabolic regulator expressed in multiple tissues including liver and adipose tissue. Although highest levels of expression are in pancreas, little is known about the function of FGF21 in this tissue. In order to understand the physiology of FGF21 in the pancreas, we analyzed its expression and regulation in both acinar and islet tissues. We found that acinar tissue express 20-fold higher levels than that observed in islets. We also observed that pancreatic FGF21 is nutritionally regulated; a marked reduction in FGF21 expression was noted with fasting while obesity is associated with 3–4 fold higher expression. Acinar and islet cells are targets of FGF21, which when systemically administered, leads to phosphorylation of the downstream target ERK 1/2 in about half of acinar cells and a small subset of islet cells. Chronic, systemic FGF21 infusion down-regulates its own expression in the pancreas. Mice lacking FGF21 develop significant islet hyperplasia and periductal lymphocytic inflammation when fed with a high fat obesogenic diet. Inflammatory infiltrates consist of TCRb+ Thy1+ T lymphocytes with increased levels of Foxp3+ regulatory T cells. Increased levels of inflammatory cells were coupled with elevated expression of cytokines such as TNFα, IFNγ and IL1β. We conclude that FGF21 acts to limit islet hyperplasia and may also prevent pancreatic inflammation.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0148252en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752212/pdf/en
dash.licenseLAAen_US
dc.subjectMedicine and Health Sciencesen
dc.subjectEndocrinologyen
dc.subjectEndocrine Physiologyen
dc.subjectGrowth Factorsen
dc.subjectFibroblast Growth Factoren
dc.subjectBiology and Life Sciencesen
dc.subjectPhysiologyen
dc.subjectAnatomyen
dc.subjectEndocrine Systemen
dc.subjectPancreasen
dc.subjectExocrine Glandsen
dc.subjectNutritionen
dc.subjectDieten
dc.subjectDiabetic Endocrinologyen
dc.subjectInsulinen
dc.subjectBiochemistryen
dc.subjectHormonesen
dc.subjectLipidsen
dc.subjectFatsen
dc.subjectImmunologyen
dc.subjectImmune Responseen
dc.subjectInflammationen
dc.subjectPathology and Laboratory Medicineen
dc.subjectSigns and Symptomsen
dc.subjectGlucagonen
dc.subjectPeptide Hormonesen
dc.subjectPhysiological Parametersen
dc.subjectBody Weighten
dc.subjectObesityen
dc.titleFibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreasen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorSinghal, Garimaen_US
dc.date.available2016-03-01T19:49:20Z
dc.identifier.doi10.1371/journal.pone.0148252*
dash.authorsorderedfalse
dash.contributor.affiliatedFisher, FFolliott
dash.contributor.affiliatedChee, Melissa
dash.contributor.affiliatedNajarian, Robert M.
dash.contributor.affiliatedSinghal, Garima
dash.contributor.affiliatedMaratos-Flier, Eleftheria
dash.contributor.affiliatedFlier, Jeffrey
dash.contributor.affiliatedBenoist, Christophe


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