Albuminuria, Cerebrovascular Disease and Cortical Atrophy: among Cognitively Normal Elderly Individuals
View/ Open
Author
Cho, Eun Bin
Shin, Hee-Young
Park, Sang Eon
Chun, Phillip
Jang, Hye Ryoun
Yang, Jin-ju
Kim, Hee Jin
Kim, Yeo Jin
Jung, Na-Yeon
Lee, Jin San
Lee, Juyoun
Jang, Young Kyoung
Jang, Eun Young
Kang, Mira
Lee, Jong-Min
Kim, Changsoo
Min, Ju-Hong
Ryu, Seungho
Na, Duk L.
Seo, Sang Won
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.1038/srep20692Metadata
Show full item recordCitation
Cho, E. B., H. Shin, S. E. Park, P. Chun, H. R. Jang, J. Yang, H. J. Kim, et al. 2016. “Albuminuria, Cerebrovascular Disease and Cortical Atrophy: among Cognitively Normal Elderly Individuals.” Scientific Reports 6 (1): 20692. doi:10.1038/srep20692. http://dx.doi.org/10.1038/srep20692.Abstract
We tested the hypothesis that decreased glomerular filtration rate and albuminuria have different roles in brain structure alterations. We enrolled 1,215 cognitively normal individuals, all of whom underwent high-resolution T1-weighted volumetric magnetic resonance imaging scans. The cerebral small vessel disease burdens were assessed with white matter hyperintensities (WMH), lacunes, and microbleeds. Subjects were considered to have an abnormally elevated urine albumin creatinine ratio if the value was ≥17 mg/g for men and ≥25 mg/g for women. Albuminuria, but not estimated glomerular filtration rate (eGFR), was associated with increased WMH burdens (p = 0.002). The data was analyzed after adjusting for age, sex, education, history of hypertension, diabetes mellitus, hyperlipidemia, ischemic heart disease, stroke, total cholesterol level, body mass index, status of smoking and alcohol drinking, and intracranial volume. Albuminuria was also associated with cortical thinning, predominantly in the frontal and occipital regions (both p < 0.01) in multiple linear regression analysis. However, eGFR was not associated with cortical thickness. Furthermore, path analysis for cortical thickness showed that albuminuria was associated with frontal thinning partially mediated by WMH burdens. The assessment of albuminuria is needed to improve our ability to identify individuals with high risk for cognitive impairments, and further institute appropriate preventive measures.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754729/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:25658423
Collections
- HMS Scholarly Articles [17917]
Contact administrator regarding this item (to report mistakes or request changes)