Androgen Receptor CAG Repeats and Body Composition Among Ariaal Men

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Androgen Receptor CAG Repeats and Body Composition Among Ariaal Men

Show simple item record Ellison, Peter Campbell, Benjamin C. Gray, Peter B. Eisenberg, Dan T. A. Sorenson, Michael D. 2009-02-11T19:28:08Z 2007
dc.identifier.citation Campbell, Benjamin C., Peter B. Gray, Dan T. A. Eisenberg, Peter Ellison, and Michael D. Sorenson. Forthcoming. Androgen receptor CAG repeats and body composition among Ariaal men. International Journal of Andrology. en
dc.identifier.issn 0105-6263 en
dc.description.abstract To determine the population variation in the androgen receptor (AR) and its association with body composition in a subsistence population, we sampled 87 settled and 65 nomadic males ages 20+ among the Ariaal of northern Kenya. Anthropometric measures included height, body mass index, fat-free mass (FFM), upper arm muscle plus bone area (AMPBA), % body fat (%BF), suprailliac skinfold (SISF), and waist-to-hip ratio. Salivary testosterone (T) was determined from both morning (Am T) and afternoon (Pm T) samples. Hair roots were obtained for genotyping AR CAG repeat length. AR CAG repeat length did not vary between the two sub-groups (overall value = 22.6 ± 3.1). Multiple regression models, controlling for age and residence, indicate that Pm T was positively associated with all measures of body composition. AR CAG repeat length was a significant positive predictor of height, FFM, %BF, SISF and waist circumference. There was a significant negative Pm T by AR CAG repeat length interaction in predicting all anthropometric measures but AMPBA. These findings provide evidence for population variation in AR CAG repeat length and suggest that both T and AR CAG length play a role in body composition in this extremely lean population. en
dc.description.sponsorship Anthropology en
dc.description.sponsorship Human Evolutionary Biology
dc.language.iso en_US en
dc.publisher Blackwell Publishing en
dc.relation.isversionof en
dash.license LAA
dc.subject population variation en
dc.subject androgen receptor en
dc.subject Africa en
dc.subject pastoral nomads en
dc.subject testosterone en
dc.title Androgen Receptor CAG Repeats and Body Composition Among Ariaal Men en
dc.relation.journal International Journal of Andrology en Ellison, Peter

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