Physical Activity, Heart Rate, Metabolic Profile, and Estradiol in Premenopausal Women

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Physical Activity, Heart Rate, Metabolic Profile, and Estradiol in Premenopausal Women

Show simple item record Ellison, Peter Andersen, Lars Bo Jasienska, Grazyna Emaus, Aina Thune, Inger Friedenreich, Christine Furberg, Anne-Sofie Veierød, Marti B. Espetvedt, Sissi 2009-02-11T21:57:43Z 2008
dc.identifier.citation Emaus A., Marit B. Veierød, Anne-Sofie Furberg, Sissi Espetvedt, Christine Friedenreich, Peter Ellison, Grazyna Jasienska, Lars Bo Andersen, Inger Thune. 2008. Physical activity, heart rate, metabolic profile and estradiol in premenopausal women. Medicine and Science in Sports and Exercise 40(6): 1022-1030. en
dc.identifier.issn 0195-9131 en
dc.description.abstract Purpose: To study whether physical inactive women with a tendency to develop metabolic syndrome have high levels of 17[beta]-estradiol (E2) of importance for breast cancer risk. Methods: Two hundred and four healthy women of reproductive age were assessed for self-reported leisure-time physical activity (LPA), resting heart rate (HR), blood pressure (BP), anthropometry, and serum glucose, lipids, and insulin [Norwegian Energy Balance and Breast Cancer Aspect (EBBA) study]. E2 was measured in daily saliva samples throughout an entire menstrual cycle. A clustered metabolic risk score [z metabolic syndrome (zMS); total cholesterol-high-density lipoprotein-cholesterol (HDL-C) ratio, insulin resistance, total fat tissue, BP, and triglycerides] was defined. Linear regression and linear mixed models were used, and confounding factors were tested. Results: Physically active women had lower fat percentage (Ptrend = 0.003) and HRs (Ptrend = 0.003) than sedentary women. We estimated an increase in E2 of 1.27 pmol[middle dot]L-1 [95% confidence interval (CI), 0.06-2.47] for each 11.7 beats[middle dot]min-1 (1 SD) increase in HR, and this corresponds to the 7% change in mean concentration of E2 for the total group. Associations with E2 were also found for fat tissue, total cholesterol-HDL-C ratio, insulin resistance, and triglycerides. A dose-response relationship was observed among the three levels of LPA and HR and zMS (Ptrend = 0.03 for LPA; Ptrend = 0.004 for HR). Women in the highest tertile of the clustered metabolic risk score had average salivary E2profiles that were markedly higher, throughout the cycle, than those of the other groups, with a cycle peak-day difference in E2 of 22-28%. Conclusion: LPA and HR were associated with metabolic risk score, and this score was associated with daily level of E2, pointing to important biologic mechanisms operating between a sedentary lifestyle and an increased breast cancer risk. en
dc.description.sponsorship Anthropology en
dc.description.sponsorship Human Evolutionary Biology
dc.language.iso en_US en
dc.publisher Lippincott, Williams & Wilkins en
dc.relation.isversionof en
dash.license LAA
dc.subject clustered metabolic score en
dc.subject pulse en
dc.subject 17a-estradiol en
dc.subject leisure time physical activity en
dc.title Physical Activity, Heart Rate, Metabolic Profile, and Estradiol in Premenopausal Women en
dc.relation.journal Medicine and Science in Sports and Exercise en Ellison, Peter

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