Antigen Processing and Presentation: TAPping into ABC Transporters
| Title: | Antigen Processing and Presentation: TAPping into ABC Transporters |
| Author: |
Gaudet, Rachelle; Procko, Erik
Note: Order does not necessarily reflect citation order of authors. |
| Citation: | Procko, Erik, and Rachelle Gaudet. Forthcoming. Antigen processing and presentation: TAPping into ABC transporters. Current Opinion in Immunology. |
| Full Text & Related Files: |
Procko Gaudet COI accepted manuscript 2009.pdf (351.9Kb; PDF) 
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| Abstract: | Adaptive, cell-mediated immunity involves the presentation of antigenic peptides on
class I MHC molecules at the cell surface. This requires an ABC transporter associated with antigen processing (TAP) to transport antigenic peptides generated in the cytosol into the endoplasmic reticulum (ER) for loading onto class I MHC. Recent crystal structures of bacterial ABC transporters suggest how the transmembrane domains of TAP form a peptide-binding cavity that acquires peptides from the cytosol, and following ATP-induced conformational changes, the peptide-binding cavity closes to the cytosol and instead opens to the ER lumen for peptide release. Extensive biochemical studies show how transport is driven by ATP binding and hydrolysis on an asymmetric pair of cytosolic nucleotide-binding domains, which are physically coupled to the peptide binding site to propagate conformational changes through the protein. |
| Published Version: | http://dx.doi.org/10.1016/j.coi.2009.02.003 |
| Terms of Use: | This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA |
| Citable link to this page: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:2624506 |
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