Antigen Processing and Presentation: TAPping into ABC Transporters
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CitationProcko, Erik, and Rachelle Gaudet. Forthcoming. Antigen processing and presentation: TAPping into ABC transporters. Current Opinion in Immunology.
AbstractAdaptive, cell-mediated immunity involves the presentation of antigenic peptides on
class I MHC molecules at the cell surface. This requires an ABC transporter associated
with antigen processing (TAP) to transport antigenic peptides generated in the cytosol
into the endoplasmic reticulum (ER) for loading onto class I MHC. Recent crystal
structures of bacterial ABC transporters suggest how the transmembrane domains of TAP
form a peptide-binding cavity that acquires peptides from the cytosol, and following
ATP-induced conformational changes, the peptide-binding cavity closes to the cytosol
and instead opens to the ER lumen for peptide release. Extensive biochemical studies
show how transport is driven by ATP binding and hydrolysis on an asymmetric pair of
cytosolic nucleotide-binding domains, which are physically coupled to the peptide binding
site to propagate conformational changes through the protein.
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