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dc.contributor.authorZhang, Chien_US
dc.contributor.authorDing, Huien_US
dc.contributor.authorHe, Miaoen_US
dc.contributor.authorLiu, Linaen_US
dc.contributor.authorLiu, Liangpingen_US
dc.contributor.authorLi, Gangen_US
dc.contributor.authorNiu, Bingen_US
dc.contributor.authorZhong, Xingwuen_US
dc.date.accessioned2016-04-01T15:47:14Z
dc.date.issued2016en_US
dc.identifier.citationZhang, Chi, Hui Ding, Miao He, Lina Liu, Liangping Liu, Gang Li, Bing Niu, and Xingwu Zhong. 2016. “Comparison of Early Changes in Ocular Surface and Inflammatory Mediators between Femtosecond Lenticule Extraction and Small-Incision Lenticule Extraction.” PLoS ONE 11 (3): e0149503. doi:10.1371/journal.pone.0149503. http://dx.doi.org/10.1371/journal.pone.0149503.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:26318495
dc.description.abstractPurpose To evaluate the short-term changes in ocular surface measures and tear inflammatory mediators after femtosecond lenticule extraction (FLEx) and small-incision lenticule extraction (SMILE) procedures. Methods: Eighteen subjects (18 eyes) underwent FLEx and 23 subjects (23 eyes) underwent SMILE in this single-center and prospective study. Central corneal sensitivity, Schirmer I test (SIT), noninvasive tear breakup time (NI-TBUT), tear meniscus height, corneal fluorescein (FL) staining, and ocular surface disease index (OSDI) were assessed in all patients. Concentrations of interleukin-1α (IL-1α), tumor necrosis factor-α (TNF-α), nerve growth factor (NGF), interferon-γ (IFN-γ), transforming growth factor-β1 (TGF-β1) and matrix metalloproteinase-9 (MMP-9) in collected tears were measured by multiplex antibody microarray. Results: Central corneal sensitivity was reduced in both groups, but the scores in the SMILE group were higher than those in the FLEx group at all time points postoperatively (P<0.01). Lower FL scores and longer NI-BUT were observed in the SMILE group 1 week after surgery (P<0.05). OSDI scores in both groups increased rapidly at 1 day and 1 week postoperatively, then returned to their preoperative levels within 1 month (P<0.05). There were no significant differences in SIT or tear meniscus height between the two groups. Lower and faster recovery of tear NGF, TGF-β1 and IL-1α concentration were found in the SMILE group compared to the FLEx group postoperatively. No significant difference was found in tear TNF-α, IFN-γ and MMP-9 for either group before or after surgery. Tear NGF, TGF-β1 and IL-1α show a correlation with ocular surface changes after FLEx or SMILE surgery. Conclusion: SMILE has superiority over FLEx in early ocular surface changes and NGF, TGF-β1 and IL-1α may contribute to the process of ocular surface recovery. Trial Registration ClinicalTrials.gov NCT02540785en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0149503en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777367/pdf/en
dash.licenseLAAen_US
dc.subjectBiology and Life Sciencesen
dc.subjectAnatomyen
dc.subjectOcular Systemen
dc.subjectOcular Anatomyen
dc.subjectCorneaen
dc.subjectMedicine and Health Sciencesen
dc.subjectImmunologyen
dc.subjectImmune Responseen
dc.subjectInflammationen
dc.subjectPathology and Laboratory Medicineen
dc.subjectSigns and Symptomsen
dc.subjectSurgical and Invasive Medical Proceduresen
dc.subjectHeaden
dc.subjectEyesen
dc.subjectOphthalmic Proceduresen
dc.subjectRefractive Surgeryen
dc.subjectPhysical Sciencesen
dc.subjectPhysicsen
dc.subjectClassical Mechanicsen
dc.subjectDamage Mechanicsen
dc.subjectBiology and life sciencesen
dc.subjectCell biologyen
dc.subjectSignal transductionen
dc.subjectCell signalingen
dc.subjectSignaling cascadesen
dc.subjectTGF-beta signaling cascadeen
dc.subjectNeuroscienceen
dc.subjectSensory Perceptionen
dc.subjectVisionen
dc.subjectVisual Acuityen
dc.subjectPsychologyen
dc.subjectSocial Sciencesen
dc.titleComparison of Early Changes in Ocular Surface and Inflammatory Mediators between Femtosecond Lenticule Extraction and Small-Incision Lenticule Extractionen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorNiu, Bingen_US
dc.date.available2016-04-01T15:47:14Z
dc.identifier.doi10.1371/journal.pone.0149503*
dash.authorsorderedfalse
dash.contributor.affiliatedNiu, Bing


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