Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis C Virus Infection: Findings From the InC3 Collaborative
Rice, Thomas M.
Cox, Andrea L.
Morris, Meghan D.
Shoukry, Naglaa H.
Dore, Gregory J.
Lloyd, Andrew R.
McGovern, Barbara H.Note: Order does not necessarily reflect citation order of authors.
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CitationPage, K., A. Mirzazadeh, T. M. Rice, J. Grebely, A. Y. Kim, A. L. Cox, M. D. Morris, et al. 2016. “Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis C Virus Infection: Findings From the InC3 Collaborative.” Open Forum Infectious Diseases 3 (1): ofw024. doi:10.1093/ofid/ofw024. http://dx.doi.org/10.1093/ofid/ofw024.
AbstractSymptomatic acute HCV infection and interferon lambda 4 (IFNL4) genotypes are important predictors of spontaneous viral clearance. Using data from a multicohort database (Injecting Cohorts [InC3] Collaborative), we establish an independent association between host IFNL4 genotype and symptoms of acute hepatitis C virus infection. This association potentially explains the higher spontaneous clearance observed in some patients with symptomatic disease.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:26318503
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