Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis C Virus Infection: Findings From the InC3 Collaborative
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Author
Page, Kimberly
Mirzazadeh, Ali
Rice, Thomas M.
Grebely, Jason
Cox, Andrea L.
Morris, Meghan D.
Hellard, Margaret
Bruneau, Julie
Shoukry, Naglaa H.
Dore, Gregory J.
Maher, Lisa
Lloyd, Andrew R.
Prins, Maria
McGovern, Barbara H.
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1093/ofid/ofw024Metadata
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Page, K., A. Mirzazadeh, T. M. Rice, J. Grebely, A. Y. Kim, A. L. Cox, M. D. Morris, et al. 2016. “Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis C Virus Infection: Findings From the InC3 Collaborative.” Open Forum Infectious Diseases 3 (1): ofw024. doi:10.1093/ofid/ofw024. http://dx.doi.org/10.1093/ofid/ofw024.Abstract
Symptomatic acute HCV infection and interferon lambda 4 (IFNL4) genotypes are important predictors of spontaneous viral clearance. Using data from a multicohort database (Injecting Cohorts [InC3] Collaborative), we establish an independent association between host IFNL4 genotype and symptoms of acute hepatitis C virus infection. This association potentially explains the higher spontaneous clearance observed in some patients with symptomatic disease.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785397/pdf/Terms of Use
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http://nrs.harvard.edu/urn-3:HUL.InstRepos:26318503
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