dc.contributor.author | Buscher, Konrad | en_US |
dc.contributor.author | Wang, Huiyu | en_US |
dc.contributor.author | Zhang, Xueli | en_US |
dc.contributor.author | Striewski, Paul | en_US |
dc.contributor.author | Wirth, Benedikt | en_US |
dc.contributor.author | Saggu, Gurpanna | en_US |
dc.contributor.author | Lütke-Enking, Stefan | en_US |
dc.contributor.author | Mayadas, Tanya N. | en_US |
dc.contributor.author | Ley, Klaus | en_US |
dc.contributor.author | Sorokin, Lydia | en_US |
dc.contributor.author | Song, Jian | en_US |
dc.date.accessioned | 2016-04-01T15:47:24Z | |
dc.date.issued | 2016 | en_US |
dc.identifier.citation | Buscher, K., H. Wang, X. Zhang, P. Striewski, B. Wirth, G. Saggu, S. Lütke-Enking, et al. 2016. “Protection from septic peritonitis by rapid neutrophil recruitment through omental high endothelial venules.” Nature Communications 7 (1): 10828. doi:10.1038/ncomms10828. http://dx.doi.org/10.1038/ncomms10828. | en |
dc.identifier.issn | 2041-1723 | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:26318516 | |
dc.description.abstract | Acute peritonitis is a frequent medical condition that can trigger severe sepsis as a life-threatening complication. Neutrophils are first-responders in infection but recruitment mechanisms to the abdominal cavity remain poorly defined. Here, we demonstrate that high endothelial venules (HEVs) of the greater omentum constitute a main entry pathway in TNFα-, Escherichia coli (E. coli)- and caecal ligation and puncture-induced models of inflammation. Neutrophil transmigration across HEVs is faster than across conventional postcapillary venules and requires a unique set of adhesion receptors including peripheral node addressin, E-, L-selectin and Mac-1 but not P-selectin or LFA-1. Omental milky spots readily concentrate intra-abdominal E. coli where macrophages and recruited neutrophils collaborate in phagocytosis and killing. Inhibition of the omental neutrophil response exacerbates septic progression of peritonitis. This data identifies HEVs as a clinically relevant vascular recruitment site for neutrophils in acute peritonitis that is indispensable for host defence against early systemic bacterial spread and sepsis. | en |
dc.language.iso | en_US | en |
dc.publisher | Nature Publishing Group | en |
dc.relation.isversionof | doi:10.1038/ncomms10828 | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785224/pdf/ | en |
dash.license | LAA | en_US |
dc.title | Protection from septic peritonitis by rapid neutrophil recruitment through omental high endothelial venules | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | Nature Communications | en |
dash.depositing.author | Saggu, Gurpanna | en_US |
dc.date.available | 2016-04-01T15:47:24Z | |
dc.identifier.doi | 10.1038/ncomms10828 | * |
dash.authorsordered | false | |
dash.contributor.affiliated | Saggu, Gurpanna | |
dash.contributor.affiliated | Mayadas, Tanya | |