Phase II study of tivantinib (ARQ 197) in patients with metastatic triple-negative breast cancer
Tolaney, Sara M.
Van Allen, Eliezer
Wright, John J.
Shapiro, Geoffrey I.
Winer, Eric P.
Krop, Ian E.Note: Order does not necessarily reflect citation order of authors.
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CitationTolaney, S. M., S. Tan, H. Guo, W. Barry, E. Van Allen, N. Wagle, J. Brock, et al. 2015. “Phase II study of tivantinib (ARQ 197) in patients with metastatic triple-negative breast cancer.” Investigational New Drugs 33 (1): 1108-1114. doi:10.1007/s10637-015-0269-8. http://dx.doi.org/10.1007/s10637-015-0269-8.
AbstractSummary Background: MET expression and activation appear to be important for initiation and progression of triple-negative breast cancer. Tivantinib (ARQ 197) is an orally administered agent that targets MET, although recent preclinical data suggests the agent may have mechanisms of action that are independent of MET signaling. We conducted a phase 2 study of tivantinib monotherapy in patients with metastatic triple-negative breast cancer. Methods: Patients with metastatic triple-negative breast cancer who had received 1 to 3 prior lines of chemotherapy in the metastatic setting were enrolled into this two-stage, single arm phase 2 study. Treatment consisted of twice daily oral dosing of tivantinib (360 mg po bid) during a 21-day cycle. Patients underwent restaging scans at 6 weeks, and then every 9 weeks. Tumor biomarkers that might predict response to tivantinib were explored. Results: 22 patients were enrolled. The overall response rate was 5 % (95 % CI 0–25 %) and the 6-month progression-free survival (PFS) was 5 % (95 % CI 0–25 %), with one patient achieving a partial response (PR). Toxicity was minimal with only 5 grade ≥3 adverse events (one grade 3 anemia, one grade 3 fatigue, and 3 patients with grade 3/4 neutropenia). Conclusion: This study represents the first evaluation of tivantinib for the treatment of metastatic triple-negative breast cancer. These results suggest that single agent tivantinib is well tolerated, but did not meet prespecified statistical targets for efficacy.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:26318525
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