Focus on Extracellular Vesicles: New Frontiers of Cell-to-Cell Communication in Cancer

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Author
Ciardiello, Chiara
Cavallini, Lorenzo
Spinelli, Cristiana
Yang, Julie
Reis-Sobreiro, Mariana
de Candia, Paola
Minciacchi, Valentina Renè
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https://doi.org/10.3390/ijms17020175Metadata
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Ciardiello, Chiara, Lorenzo Cavallini, Cristiana Spinelli, Julie Yang, Mariana Reis-Sobreiro, Paola de Candia, Valentina Renè Minciacchi, and Dolores Di Vizio. 2016. “Focus on Extracellular Vesicles: New Frontiers of Cell-to-Cell Communication in Cancer.” International Journal of Molecular Sciences 17 (2): 175. doi:10.3390/ijms17020175. http://dx.doi.org/10.3390/ijms17020175.Abstract
Extracellular Vesicles (EVs) have received considerable attention in recent years, both as mediators of intercellular communication pathways that lead to tumor progression, and as potential sources for discovery of novel cancer biomarkers. For many years, research on EVs has mainly investigated either the mechanism of biogenesis and cargo selection and incorporation, or the methods of EV isolation from available body fluids for biomarker discovery. Recent studies have highlighted the existence of different populations of cancer-derived EVs, with distinct molecular cargo, thus pointing to the possibility that the various EV populations might play diverse roles in cancer and that this does not happen randomly. However, data attributing cancer specific intercellular functions to given populations of EVs are still limited. A deeper functional, biochemical and molecular characterization of the various EV classes might identify more selective clinical markers, and significantly advance our knowledge of the pathogenesis and disease progression of many cancer types.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783909/pdf/Terms of Use
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