Changes in Body Composition over Eight Years in a Randomized Trial of a Lifestyle Intervention: The Look AHEAD Study
Pownall, Henry J.
Bray, George A.
Wagenknecht, Lynne E.
Walkup, Michael P.
Hubbard, Van S.
Kahn, Steven E.
Schwartz, Anne V.
Johnson, Karen C.Note: Order does not necessarily reflect citation order of authors.
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CitationPownall, H. J., G. A. Bray, L. E. Wagenknecht, M. P. Walkup, S. Heshka, V. S. Hubbard, J. Hill, et al. 2014. “Changes in Body Composition over Eight Years in a Randomized Trial of a Lifestyle Intervention: The Look AHEAD Study.” Obesity (Silver Spring, Md.) 23 (3): 565-572. doi:10.1002/oby.21005. http://dx.doi.org/10.1002/oby.21005.
AbstractObjective: To determine the effects of an intensive lifestyle intervention vs. a comparison group on body composition in obese or overweight persons with type 2 diabetes at baseline and at 1, 4, and 8 years. Design and Methods Body composition was measured by dual energy X-ray absorptiometry in a subset of 1019 Look Ahead study volunteers randomized to intervention or comparison groups. The intervention was designed to achieve and maintain ≥7% weight loss through increased physical activity and reduced caloric intake. The comparison group received social support and diabetes education. Results: At 1 year, the intervention group lost fat (5.6 ± 0.2 kg) and lean mass (2.3 ± 0.1 kg) but regained fat (~100%), and lost lean mass between years 1 and 8. Between baseline and year-8, weight-loss was greater in intervention vs. comparison groups (4.0 ± 0.4 vs. 2.3 ± 0.4 kg); comparison group weight-loss was mostly lean mass (2.1 ± 0.17 kg). Fat mass in the intervention group was lower than that of the comparison group at all post-baseline time points. Conclusions: Reduced FM may place the intervention group at a lower risk of obesity-linked sequelae, a hypothesis that can be tested by future studies of this cohort. Trial Registration ClinicalTrials.gov Identifier: NCT00017953
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:26318582
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