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dc.contributor.authorDeng, Guo-Minen_US
dc.contributor.authorKyttaris, Vasileios C.en_US
dc.contributor.authorTsokos, George C.en_US
dc.date.accessioned2016-04-01T15:47:55Z
dc.date.issued2016en_US
dc.identifier.citationDeng, Guo-Min, Vasileios C. Kyttaris, and George C. Tsokos. 2016. “Targeting Syk in Autoimmune Rheumatic Diseases.” Frontiers in Immunology 7 (1): 78. doi:10.3389/fimmu.2016.00078. http://dx.doi.org/10.3389/fimmu.2016.00078.en
dc.identifier.issn1664-3224en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:26318606
dc.description.abstractSpleen tyrosine kinase (Syk) is a member of the Src family of non-receptor tyrosine kinases, which associates directly with surface receptors, including B-cell receptor and Fcγ receptor, and is involved in a variety of signal transduction pathways. Rheumatoid arthritis (RA) and systemic lupus erythematosus are autoimmune diseases in which autoantibodies, immune complexes, and autoreactive T cells account for the expression of tissue inflammation and damage. Syk inhibitors efficiently suppress RA in patients albeit in the expression of unwanted side effects, including gastrointestinal effects, hypertension, and neutropenia. Syk inhibitors also inhibit clinical manifestations in lupus-prone mice. Here, we review the evidence that supports the use of Syk inhibitors to treat rheumatic and other autoimmune diseases.en
dc.language.isoen_USen
dc.publisherFrontiers Media S.A.en
dc.relation.isversionofdoi:10.3389/fimmu.2016.00078en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779881/pdf/en
dash.licenseLAAen_US
dc.subjectMini Reviewen
dc.subjectSyken
dc.subjectautoimmune diseaseen
dc.subjectSyk inhibitoren
dc.subjectIgGen
dc.subjectFcgamma receptorsen
dc.titleTargeting Syk in Autoimmune Rheumatic Diseasesen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalFrontiers in Immunologyen
dash.depositing.authorKyttaris, Vasileios C.en_US
dc.date.available2016-04-01T15:47:55Z
dc.identifier.doi10.3389/fimmu.2016.00078*
dash.contributor.affiliatedKyttaris, Vasileios
dash.contributor.affiliatedTsokos, George


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