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dc.contributor.authorGuney, Emreen_US
dc.contributor.authorMenche, Jörgen_US
dc.contributor.authorVidal, Marcen_US
dc.contributor.authorBarábasi, Albert-Lászlóen_US
dc.date.accessioned2016-04-01T15:48:01Z
dc.date.issued2016en_US
dc.identifier.citationGuney, Emre, Jörg Menche, Marc Vidal, and Albert-László Barábasi. 2016. “Network-based in silico drug efficacy screening.” Nature Communications 7 (1): 10331. doi:10.1038/ncomms10331. http://dx.doi.org/10.1038/ncomms10331.en
dc.identifier.issn2041-1723en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:26318623
dc.description.abstractThe increasing cost of drug development together with a significant drop in the number of new drug approvals raises the need for innovative approaches for target identification and efficacy prediction. Here, we take advantage of our increasing understanding of the network-based origins of diseases to introduce a drug-disease proximity measure that quantifies the interplay between drugs targets and diseases. By correcting for the known biases of the interactome, proximity helps us uncover the therapeutic effect of drugs, as well as to distinguish palliative from effective treatments. Our analysis of 238 drugs used in 78 diseases indicates that the therapeutic effect of drugs is localized in a small network neighborhood of the disease genes and highlights efficacy issues for drugs used in Parkinson and several inflammatory disorders. Finally, network-based proximity allows us to predict novel drug-disease associations that offer unprecedented opportunities for drug repurposing and the detection of adverse effects.en
dc.language.isoen_USen
dc.publisherNature Publishing Groupen
dc.relation.isversionofdoi:10.1038/ncomms10331en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740350/pdf/en
dash.licenseLAAen_US
dc.titleNetwork-based in silico drug efficacy screeningen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNature Communicationsen
dash.depositing.authorVidal, Marcen_US
dc.date.available2016-04-01T15:48:01Z
dc.identifier.doi10.1038/ncomms10331*
dash.contributor.affiliatedBarabasi, Albert-Laszlo
dash.contributor.affiliatedVidal, Marc


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