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dc.contributor.authorNemeth, Zsuzsannaen_US
dc.contributor.authorLi, Mailinen_US
dc.contributor.authorCsizmadia, Evaen_US
dc.contributor.authorDöme, Balazsen_US
dc.contributor.authorJohansson, Martinen_US
dc.contributor.authorPersson, Jenny Liaoen_US
dc.contributor.authorSeth, Pankajen_US
dc.contributor.authorOtterbein, Leoen_US
dc.contributor.authorWegiel, Barbaraen_US
dc.date.accessioned2016-04-01T15:48:02Z
dc.date.issued2015en_US
dc.identifier.citationNemeth, Zsuzsanna, Mailin Li, Eva Csizmadia, Balazs Döme, Martin Johansson, Jenny Liao Persson, Pankaj Seth, Leo Otterbein, and Barbara Wegiel. 2015. “Heme oxygenase-1 in macrophages controls prostate cancer progression.” Oncotarget 6 (32): 33675-33688.en
dc.identifier.issn1949-2553en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:26318629
dc.description.abstractInnate immune cells strongly influence cancer growth and progression via multiple mechanisms including regulation of epithelial to mesenchymal transition (EMT). In this study, we investigated whether expression of the metabolic gene, heme oxygenase-1 (HO-1) in tumor microenvironment imparts significant effects on prostate cancer progression. We showed that HO-1 is expressed in MARCO-positive macrophages in prostate cancer (PCa) xenografts and human prostate cancers. We demonstrated that macrophage specific (LyzM-Cre) conditional deletion of HO-1 suppressed growth of PC3 xenografts in vivo and delayed progression of prostate intraepithelial neoplasia (PIN) in TRAMP mice. However, initiation and progression of cancer xenografts in the presence of macrophages lacking HO-1 resulted in loss of E-cadherin, a known marker of poor prognosis as well as EMT. Application of CO, a product of HO-1 catalysis, increased levels of E-cadherin in the adherens junctions between cancer cells. We further showed that HO-1-driven expression of E-cadherin in cancer cells cultured in the presence of macrophages is dependent on mitochondrial activity of cancer cells. In summary, these data suggest that HO-1-derived CO from tumor-associated macrophages influences, in part, E-cadherin expression and thus tumor initiation and progression.en
dc.language.isoen_USen
dc.publisherImpact Journals LLCen
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741794/pdf/en
dash.licenseLAAen_US
dc.subjecttumor-associated macrophagesen
dc.subjectmitochondriaen
dc.subjectheme oxygenase-1en
dc.subjectE-cadherinen
dc.subjecttumor microenvironmenten
dc.titleHeme oxygenase-1 in macrophages controls prostate cancer progressionen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalOncotargeten
dash.depositing.authorSeth, Pankajen_US
dc.date.available2016-04-01T15:48:02Z
dash.contributor.affiliatedWegiel, Barbara
dash.contributor.affiliatedSeth, Pankaj
dash.contributor.affiliatedOtterbein, Leo


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