dc.contributor.author | Bergamino, Maurizio | en_US |
dc.contributor.author | Pasternak, Ofer | en_US |
dc.contributor.author | Farmer, Madison | en_US |
dc.contributor.author | Shenton, Martha E. | en_US |
dc.contributor.author | Paul Hamilton, J. | en_US |
dc.date.accessioned | 2016-04-01T15:48:15Z | |
dc.date.issued | 2015 | en_US |
dc.identifier.citation | Bergamino, Maurizio, Ofer Pasternak, Madison Farmer, Martha E. Shenton, and J. Paul Hamilton. 2015. “Applying a free-water correction to diffusion imaging data uncovers stress-related neural pathology in depression.” NeuroImage : Clinical 10 (1): 336-342. doi:10.1016/j.nicl.2015.11.020. http://dx.doi.org/10.1016/j.nicl.2015.11.020. | en |
dc.identifier.issn | 2213-1582 | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:26318670 | |
dc.description.abstract | Diffusion tensor imaging (DTI) holds promise for developing our understanding of white-matter pathology in major depressive disorder (MDD). Variable findings in DTI-based investigations of MDD, however, have thwarted development of this literature. Effects of extra-cellular free-water on the sensitivity of DTI metrics could account for some of this inconsistency. Here we investigated whether applying a free-water correction algorithm to DTI data could improve the sensitivity to detect clinical effects using DTI metrics. Only after applying this correction, we found: a) significantly decreased fractional anisotropy and axial diffusivity (AD) in the left inferior fronto-occipital fasciculus (IFOF) in MDD; and b) increased self-reported stress that significantly correlated with decreased IFOF AD in depression. We estimated and confirmed the robustness of differences observed between free-water corrected and uncorrected approaches using bootstrapping. We conclude that applying a free-water correction to DTI data increases the sensitivity of DTI-based metrics to detect clinical effects in MDD. | en |
dc.language.iso | en_US | en |
dc.publisher | Elsevier | en |
dc.relation.isversionof | doi:10.1016/j.nicl.2015.11.020 | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788504/pdf/ | en |
dash.license | LAA | en_US |
dc.subject | Diffusion tensor imaging | en |
dc.subject | Free-water corrected DTI | en |
dc.subject | Major depressive disorder | en |
dc.subject | Tract-based spatial statistics | en |
dc.subject | Fractional anisotropy | en |
dc.subject | Axial diffusivity | en |
dc.title | Applying a free-water correction to diffusion imaging data uncovers stress-related neural pathology in depression | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | NeuroImage : Clinical | en |
dash.depositing.author | Pasternak, Ofer | en_US |
dc.date.available | 2016-04-01T15:48:15Z | |
dc.identifier.doi | 10.1016/j.nicl.2015.11.020 | * |
dash.identifier.orcid | 0000-0003-4235-7879 | en_US |
dash.contributor.affiliated | Pasternak, Ofer | |
dash.contributor.affiliated | Shenton, Martha | |