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dc.contributor.authorBergamino, Maurizioen_US
dc.contributor.authorPasternak, Oferen_US
dc.contributor.authorFarmer, Madisonen_US
dc.contributor.authorShenton, Martha E.en_US
dc.contributor.authorPaul Hamilton, J.en_US
dc.date.accessioned2016-04-01T15:48:15Z
dc.date.issued2015en_US
dc.identifier.citationBergamino, Maurizio, Ofer Pasternak, Madison Farmer, Martha E. Shenton, and J. Paul Hamilton. 2015. “Applying a free-water correction to diffusion imaging data uncovers stress-related neural pathology in depression.” NeuroImage : Clinical 10 (1): 336-342. doi:10.1016/j.nicl.2015.11.020. http://dx.doi.org/10.1016/j.nicl.2015.11.020.en
dc.identifier.issn2213-1582en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:26318670
dc.description.abstractDiffusion tensor imaging (DTI) holds promise for developing our understanding of white-matter pathology in major depressive disorder (MDD). Variable findings in DTI-based investigations of MDD, however, have thwarted development of this literature. Effects of extra-cellular free-water on the sensitivity of DTI metrics could account for some of this inconsistency. Here we investigated whether applying a free-water correction algorithm to DTI data could improve the sensitivity to detect clinical effects using DTI metrics. Only after applying this correction, we found: a) significantly decreased fractional anisotropy and axial diffusivity (AD) in the left inferior fronto-occipital fasciculus (IFOF) in MDD; and b) increased self-reported stress that significantly correlated with decreased IFOF AD in depression. We estimated and confirmed the robustness of differences observed between free-water corrected and uncorrected approaches using bootstrapping. We conclude that applying a free-water correction to DTI data increases the sensitivity of DTI-based metrics to detect clinical effects in MDD.en
dc.language.isoen_USen
dc.publisherElsevieren
dc.relation.isversionofdoi:10.1016/j.nicl.2015.11.020en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788504/pdf/en
dash.licenseLAAen_US
dc.subjectDiffusion tensor imagingen
dc.subjectFree-water corrected DTIen
dc.subjectMajor depressive disorderen
dc.subjectTract-based spatial statisticsen
dc.subjectFractional anisotropyen
dc.subjectAxial diffusivityen
dc.titleApplying a free-water correction to diffusion imaging data uncovers stress-related neural pathology in depressionen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNeuroImage : Clinicalen
dash.depositing.authorPasternak, Oferen_US
dc.date.available2016-04-01T15:48:15Z
dc.identifier.doi10.1016/j.nicl.2015.11.020*
dash.identifier.orcid0000-0003-4235-7879en_US
dash.contributor.affiliatedPasternak, Ofer
dash.contributor.affiliatedShenton, Martha


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