Gelsolin and Progression of Aortic Arch Calcification in Chronic Hemodialysis Patients

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Gelsolin and Progression of Aortic Arch Calcification in Chronic Hemodialysis Patients

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dc.contributor.author Chiou, Terry Ting-Yu en_US
dc.contributor.author Liao, Shang-Chih en_US
dc.contributor.author Kao, Yu-Yin en_US
dc.contributor.author Lee, Wen-Chin en_US
dc.contributor.author Lee, Yueh-Ting en_US
dc.contributor.author Ng, Hwee-Yeong en_US
dc.contributor.author Lee, Po-Shun en_US
dc.contributor.author Lee, Chien-Te en_US
dc.date.accessioned 2016-04-01T15:48:15Z
dc.date.issued 2016 en_US
dc.identifier.citation Chiou, Terry Ting-Yu, Shang-Chih Liao, Yu-Yin Kao, Wen-Chin Lee, Yueh-Ting Lee, Hwee-Yeong Ng, Po-Shun Lee, and Chien-Te Lee. 2016. “Gelsolin and Progression of Aortic Arch Calcification in Chronic Hemodialysis Patients.” International Journal of Medical Sciences 13 (2): 92-98. doi:10.7150/ijms.13785. http://dx.doi.org/10.7150/ijms.13785. en
dc.identifier.issn 1449-1907 en
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:26318672
dc.description.abstract Background:Vascular calcification (VC) is a key process associated with cardiovascular mortality in dialysis patients. Gelsolin is an actin-binding protein that can modulate inflammation, correlated inversely with hemodialysis (HD) mortality and involved in bone calcification homeostasis. In this report, we aim to characterize progression in aortic arch calcification (AAC) and investigate its association with gelsolin. Methods: 184 HD patients were enrolled and their annual posterior-anterior chest X-ray films (CXR) in 2009 and 2013 were examined. The severity of AAC was classified as grade 0 to 3. Blood levels of gelsolin were measured by ELISA kits. Biographic and biochemical data at baseline were analyzed with status of AAC at baseline and changes after 4 years. Results: At baseline, 60% of the patients had detectable AAC on CXR. After 4 years, 77% had AAC. Patients with grade 1 and 2 AAC had increased risk of progression (Odds ratio [OR] 2~3, P=0.001) compared to those with grade 0 at baseline. Compared to those with no AAC, patients with AAC progression had older age, lower gelsolin, higher waist circumference and prevalence of vascular disease. Regression analysis confirmed baseline gelsolin (odds ratio 0.845, 95% confidence interval [0.734-0.974]) and waist circumference as the independent factors associated with AAC progression. Gelsolin is positively correlated with serum albumin and negatively with tumor necrosis factor-alpha. Conclusion: Our study demonstrated that HD patients with grades 1 or 2 baseline AAC are at increased risk of further progression compared to those with grade 0. We also found lower blood levels of gelsolin associated with progressive AAC. Further investigation into the mechanistic roles of gelsolin in vascular calcification may provide new understanding of this key process. en
dc.language.iso en_US en
dc.publisher Ivyspring International Publisher en
dc.relation.isversionof doi:10.7150/ijms.13785 en
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764774/pdf/ en
dash.license LAA en_US
dc.subject Aortic arch calcification en
dc.subject gelsolin en
dc.subject hemodialysis. en
dc.title Gelsolin and Progression of Aortic Arch Calcification in Chronic Hemodialysis Patients en
dc.type Journal Article en_US
dc.description.version Version of Record en
dc.relation.journal International Journal of Medical Sciences en
dc.date.available 2016-04-01T15:48:15Z

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