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dc.contributor.authorLiu, Yu-Lien_US
dc.contributor.authorWang, Sheng-Changen_US
dc.contributor.authorHwu, Hai-Gwoen_US
dc.contributor.authorFann, Cathy Shen-Jangen_US
dc.contributor.authorYang, Ueng-Chengen_US
dc.contributor.authorYang, Wei-Chihen_US
dc.contributor.authorHsu, Pei-Chunen_US
dc.contributor.authorChang, Chien-Chingen_US
dc.contributor.authorWen, Chun-Chiangen_US
dc.contributor.authorTsai-Wu, Jyy-Jihen_US
dc.contributor.authorHwang, Tzung-Jengen_US
dc.contributor.authorHsieh, Ming H.en_US
dc.contributor.authorLiu, Chen-Chungen_US
dc.contributor.authorChien, Yi-Lingen_US
dc.contributor.authorFang, Chiu-Pingen_US
dc.contributor.authorFaraone, Stephen V.en_US
dc.contributor.authorTsuang, Ming T.en_US
dc.contributor.authorChen, Wei J.en_US
dc.contributor.authorLiu, Chih-Minen_US
dc.date.accessioned2016-04-01T15:48:19Z
dc.date.issued2016en_US
dc.identifier.citationLiu, Y., S. Wang, H. Hwu, C. S. Fann, U. Yang, W. Yang, P. Hsu, et al. 2016. “Haplotypes of the D-Amino Acid Oxidase Gene Are Significantly Associated with Schizophrenia and Its Neurocognitive Deficits.” PLoS ONE 11 (3): e0150435. doi:10.1371/journal.pone.0150435. http://dx.doi.org/10.1371/journal.pone.0150435.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:26318683
dc.description.abstractD-amino acid oxidase (DAO) has been reported to be associated with schizophrenia. This study aimed to search for genetic variants associated with this gene. The genomic regions of all exons, highly conserved regions of introns, and promoters of this gene were sequenced. Potentially meaningful single-nucleotide polymorphisms (SNPs) obtained from direct sequencing were selected for genotyping in 600 controls and 912 patients with schizophrenia and in a replicated sample consisting of 388 patients with schizophrenia. Genetic associations were examined using single-locus and haplotype association analyses. In single-locus analyses, the frequency of the C allele of a novel SNP rs55944529 located at intron 8 was found to be significantly higher in the original large patient sample (p = 0.016). This allele was associated with a higher level of DAO mRNA expression in the Epstein-Barr virus-transformed lymphocytes. The haplotype distribution of a haplotype block composed of rs11114083-rs2070586-rs2070587-rs55944529 across intron 1 and intron 8 was significantly different between the patients and controls and the haplotype frequencies of AAGC were significantly higher in patients, in both the original (corrected p < 0.0001) and replicated samples (corrected p = 0.0003). The CGTC haplotype was specifically associated with the subgroup with deficits in sustained attention and executive function and the AAGC haplotype was associated with the subgroup without such deficits. The DAO gene was a susceptibility gene for schizophrenia and the genomic region between intron 1 and intron 8 may harbor functional genetic variants, which may influence the mRNA expression of DAO and neurocognitive functions in schizophrenia.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0150435en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795637/pdf/en
dash.licenseLAAen_US
dc.subjectBiology and Life Sciencesen
dc.subjectEvolutionary Biologyen
dc.subjectPopulation Geneticsen
dc.subjectHaplotypesen
dc.subjectGeneticsen
dc.subjectPopulation Biologyen
dc.subjectMedicine and Health Sciencesen
dc.subjectMental Health and Psychiatryen
dc.subjectSchizophreniaen
dc.subjectComputational Biologyen
dc.subjectGenome Complexityen
dc.subjectIntronsen
dc.subjectGenomicsen
dc.subjectNeuroscienceen
dc.subjectCognitive Scienceen
dc.subjectCognitive Neuroscienceen
dc.subjectCognitive Neurologyen
dc.subjectNeuropsychological Testingen
dc.subjectContinuous Performance Testsen
dc.subjectNeurologyen
dc.subjectNeuropsychologyen
dc.subjectPsychologyen
dc.subjectSocial Sciencesen
dc.subjectMolecular Biologyen
dc.subjectMolecular Biology Techniquesen
dc.subjectSequencing Techniquesen
dc.subjectDirect Sequencingen
dc.subjectHuman Geneticsen
dc.subjectGene Expressionen
dc.subjectGenotypingen
dc.titleHaplotypes of the D-Amino Acid Oxidase Gene Are Significantly Associated with Schizophrenia and Its Neurocognitive Deficitsen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorTsuang, Ming T.en_US
dc.date.available2016-04-01T15:48:19Z
dc.identifier.doi10.1371/journal.pone.0150435*
dash.authorsorderedfalse
dash.contributor.affiliatedTsuang, Ming


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