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dc.contributor.authorNorby, Faye L.en_US
dc.contributor.authorEryd, Samuel Adamssonen_US
dc.contributor.authorNiemeijer, Maartje N.en_US
dc.contributor.authorRose, Lynda M.en_US
dc.contributor.authorSmith, Albert V.en_US
dc.contributor.authorYin, Xiaoyanen_US
dc.contributor.authorAgarwal, Sunil K.en_US
dc.contributor.authorArking, Dan E.en_US
dc.contributor.authorChasman, Daniel L.en_US
dc.contributor.authorChen, Lin Y.en_US
dc.contributor.authorEijgelsheim, Marken_US
dc.contributor.authorEngström, Gunnaren_US
dc.contributor.authorFranco, Oscar H.en_US
dc.contributor.authorHeeringa, Janen_US
dc.contributor.authorHindy, Georgeen_US
dc.contributor.authorHofman, Alberten_US
dc.contributor.authorLutsey, Pamela L.en_US
dc.contributor.authorMagnani, Jared W.en_US
dc.contributor.authorMcManus, David D.en_US
dc.contributor.authorOrho-Melander, Marjuen_US
dc.contributor.authorPankow, James S.en_US
dc.contributor.authorRukh, Gullen_US
dc.contributor.authorSchulz, Christina-Alexandraen_US
dc.contributor.authorUitterlinden, André G.en_US
dc.contributor.authorAlbert, Christine M.en_US
dc.contributor.authorBenjamin, Emelia J.en_US
dc.contributor.authorGudnason, Vilmunduren_US
dc.contributor.authorSmith, J. Gustaven_US
dc.contributor.authorStricker, Bruno H. C.en_US
dc.contributor.authorAlonso, Alvaroen_US
dc.date.accessioned2016-04-01T15:48:20Z
dc.date.issued2016en_US
dc.identifier.citationNorby, F. L., S. A. Eryd, M. N. Niemeijer, L. M. Rose, A. V. Smith, X. Yin, S. K. Agarwal, et al. 2016. “Association of Lipid-Related Genetic Variants with the Incidence of Atrial Fibrillation: The AFGen Consortium.” PLoS ONE 11 (3): e0151932. doi:10.1371/journal.pone.0151932. http://dx.doi.org/10.1371/journal.pone.0151932.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:26318686
dc.description.abstractBackground: Several studies have shown associations between blood lipid levels and the risk of atrial fibrillation (AF). To test the potential effect of blood lipids with AF risk, we assessed whether previously developed lipid gene scores, used as instrumental variables, are associated with the incidence of AF in 7 large cohorts. Methods: We analyzed 64,901 individuals of European ancestry without previous AF at baseline and with lipid gene scores. Lipid-specific gene scores, based on loci significantly associated with lipid levels, were calculated. Additionally, non-pleiotropic gene scores for high-density lipoprotein cholesterol (HDLc) and low-density lipoprotein cholesterol (LDLc) were calculated using SNPs that were only associated with the specific lipid fraction. Cox models were used to estimate the hazard ratio (HR) and 95% confidence intervals (CI) of AF per 1-standard deviation (SD) increase of each lipid gene score. Results: During a mean follow-up of 12.0 years, 5434 (8.4%) incident AF cases were identified. After meta-analysis, the HDLc, LDLc, total cholesterol, and triglyceride gene scores were not associated with incidence of AF. Multivariable-adjusted HR (95% CI) were 1.01 (0.98–1.03); 0.98 (0.96–1.01); 0.98 (0.95–1.02); 0.99 (0.97–1.02), respectively. Similarly, non-pleiotropic HDLc and LDLc gene scores showed no association with incident AF: HR (95% CI) = 1.00 (0.97–1.03); 1.01 (0.99–1.04). Conclusions: In this large cohort study of individuals of European ancestry, gene scores for lipid fractions were not associated with incident AF.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0151932en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801208/pdf/en
dash.licenseLAAen_US
dc.subjectMedicine and Health Sciencesen
dc.subjectCardiologyen
dc.subjectArrhythmiaen
dc.subjectAtrial Fibrillationen
dc.subjectBiology and Life Sciencesen
dc.subjectBiochemistryen
dc.subjectLipidsen
dc.subjectCholesterolen
dc.subjectMolecular Biologyen
dc.subjectMacromolecular Structure Analysisen
dc.subjectLipid Analysisen
dc.subjectVascular Medicineen
dc.subjectBlood Pressureen
dc.subjectProteinsen
dc.subjectLipoproteinsen
dc.subjectHeart Failureen
dc.subjectCoronary Heart Diseaseen
dc.titleAssociation of Lipid-Related Genetic Variants with the Incidence of Atrial Fibrillation: The AFGen Consortiumen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorAlbert, Christine M.en_US
dc.date.available2016-04-01T15:48:20Z
dc.identifier.doi10.1371/journal.pone.0151932*
dash.authorsorderedfalse
dash.contributor.affiliatedAlbert, Christine


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