TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection
Jacques, Miye K.
Steblenko, Katherine M.
Stowell, Britni L.
Behar, Samuel M.
MetadataShow full item record
CitationJayaraman, Pushpa, Miye K. Jacques, Chen Zhu, Katherine M. Steblenko, Britni L. Stowell, Asaf Madi, Ana C. Anderson, Vijay K. Kuchroo, and Samuel M. Behar. 2016. “TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection.” PLoS Pathogens 12 (3): e1005490. doi:10.1371/journal.ppat.1005490. http://dx.doi.org/10.1371/journal.ppat.1005490.
AbstractWhile T cell immunity initially limits Mycobacterium tuberculosis infection, why T cell immunity fails to sterilize the infection and allows recrudescence is not clear. One hypothesis is that T cell exhaustion impairs immunity and is detrimental to the outcome of M. tuberculosis infection. Here we provide functional evidence for the development T cell exhaustion during chronic TB. Second, we evaluate the role of the inhibitory receptor T cell immunoglobulin and mucin domain–containing-3 (TIM3) during chronic M. tuberculosis infection. We find that TIM3 expressing T cells accumulate during chronic infection, co-express other inhibitory receptors including PD1, produce less IL-2 and TNF but more IL-10, and are functionally exhausted. Finally, we show that TIM3 blockade restores T cell function and improves bacterial control, particularly in chronically infected susceptible mice. These data show that T cell immunity is suboptimal during chronic M. tuberculosis infection due to T cell exhaustion. Moreover, in chronically infected mice, treatment with anti-TIM3 mAb is an effective therapeutic strategy against tuberculosis.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:26318699